sodium hydroxide in 1,4-dioxane T=100°C; 2 h;

1: 1-phenyl-4-hydroxy-2(1H)-quinolinone With sodium hydroxide in water T=4 - 80°C; 2: chloroform in water T=80°C; Reimer-Tiemann reaction; 13.6667 h; 3: With sulfuric acid in water T=20°C;

1: 66 percent / ethane-1,2-diol / 190 °C 2: 81 percent / 2 N aq. NaOH / dioxane / 2 h / 100 °C View Scheme