[5-(3-氯苯基)异噁唑-3-基]甲醇合成路线 （共 6 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; 1 h;
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS, INC.
Patent: US2007/259860 A1, 2007 ;
Location in patent: Page/Page column 14; 15 ;
US 20070259860 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; 1 h;
2: With water in tetrahydrofuran
参考文献
ASTRAZENECA AB
Patent: WO2008/41075 A1, 2008 ;
Location in patent: Page/Page column 41 ;
WO 2008/041075 A1
反应条件
1: hydroxylamine hydrochloride / ethanol / 6 h / Reflux
2: sodium tetrahydroborate / tetrahydrofuran; ethanol / 4 h / 0 °C
View Scheme
参考文献
Lopopolo, Gianfranco; Fiorella, Filomena; De Candia, Modesto; Nicolotti, Orazio; Martel, Sophie; Carrupt, Pierre-Alain; Altomare, Cosimo
European Journal of Pharmaceutical Sciences, 2011 , vol. 42, # 3 p. 180 - 191
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / 0 °C / Inert atmosphere
1.2: 3 h / 20 °C / Inert atmosphere
2.1: hydroxylamine hydrochloride / ethanol / 6 h / Reflux
3.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 4 h / 0 °C
View Scheme
参考文献
Lopopolo, Gianfranco; Fiorella, Filomena; De Candia, Modesto; Nicolotti, Orazio; Martel, Sophie; Carrupt, Pierre-Alain; Altomare, Cosimo
European Journal of Pharmaceutical Sciences, 2011 , vol. 42, # 3 p. 180 - 191
反应条件
1: With potassium permanganate in acetone
T=10°C; 2 h;
2: With hydrogenchloride in water
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS, INC.
Patent: US2007/37820 A1, 2007 ;
Location in patent: Page/Page column 18-19 ;
US 20070037820 A1
反应条件
pyridinium chlorochromate in dichloromethane
T=20°C;
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2007/40982 A1, 2007 ;
Location in patent: Page/Page column 13; 19 ;
WO 2007/040982 A1
