1: With tetrahydrofuran; triethylamine in diethyl ether; toluene
T=0°C; 5 h;
2: With hydrogenchloride; water in diethyl ether; toluene
3: With methanol; potassium hydroxide; water
T=45°C; 0.5 h;
参考文献
ASTRAZENECA AB
Patent: WO2008/41075 A1, 2008 ;
Location in patent: Page/Page column 42-43 ;
WO 2008/041075 A1
1: With triethylamine in tetrahydrofuran; 2-methyl tetrahydrofuran; toluene
T=-5°C;
2: With hydrogenchloride; water in tetrahydrofuran; 2-methyl tetrahydrofuran; toluene
T=50°C;
3: With sodium hydroxide in tetrahydrofuran; 2-methyl tetrahydrofuran; water; toluene
T=50°C; 0.5 h;
1: With triethylamine in tetrahydrofuran; diethyl ether; toluene
T=0°C; 5 h;
2: With hydrogenchloride; water in tetrahydrofuran; diethyl ether; toluene
3: With methanol; potassium hydroxide; water
T=45°C; 0.5 h;
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS, INC.
Patent: US2007/259895 A1, 2007 ;
Location in patent: Page/Page column 10 ;
US 20070259895 A1
