2-氯-3-三氟甲基吡啶合成路线 （共 48 条）
反应条件
1: With trichlorophosphate in 1,2-dichloro-ethane T=105 - 125°C; 7 h; 2: With triethylamine in 1,2-dichloro-ethane T=-30 - -20°C; 3 h;
参考文献
US2012/259125 A1, ;
Page/Page column 3 ;
反应条件
1: With trichlorophosphate in 1,2-dichloro-ethane T=-30 - -20°C; 1 h; 2: With triethylamine in 1,2-dichloro-ethane T=-30 - -20°C; 3 h; Product distribution / selectivity;
参考文献
US2012/259125 A1, ;
Page/Page column 3 ;
反应条件
potassium fluoride; copper(l) iodide in 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide T=25°C; 6 h;
参考文献
European Journal of Organic Chemistry, , # 2 p. 327 - 330
反应条件
in N,N-dimethyl-formamide T=100°C; 8 h; Sealed tubeInert atmosphere; regioselective reaction;
参考文献
Organic Letters, , vol. 16, # 6 p. 1744 - 1747
反应条件
1.1: dihydrogen peroxide / acetic acid / 7 h / 20 - 90 °C 1.2: 3 h / 30 - 40 °C 1.3: pH 8 2.1: trichlorophosphate / 1,2-dichloro-ethane / 1 h / -30 - -20 °C 2.2: 3 h / -30 - -20 °C View Scheme
反应条件
zinc cyanide; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in DMF (N,N-dimethyl-formamide); dichloromethane 4 h; Heating / reflux;
参考文献
WO2004/74290 A1, ;
Page 45 ;
WO 2004/074290 A1
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) in DMF (N,N-dimethyl-formamide); water T=120°C; 6.5 h;
参考文献
WO2005/7652 A2, ;
Page/Page column 57 ;
WO 2005/007652 A2
反应条件
1: in water; N,N-dimethyl-formamide T=20°C; 0.25 h; 2: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium(0) in DMF (N,N-dimethyl-formamide); water T=120°C; 1 h;
参考文献
US2005/215575 A1, ;
Page/Page column 21 ;
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; sodium formate; palladium on activated charcoal in water; ethylene glycol; toluene Heating; Further byproducts given;
参考文献
Munavalli, S.; Rossman, D. I.; Szafraniec, L. L.; Beaudry, W. T.; Rohrbaugh, D. K.; et al.
Journal of Fluorine Chemistry, 1995 , vol. 73, # 1 p. 1 - 6
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; sodium formate; palladium on activated charcoal in water; ethylene glycol; toluene Heating; Further byproducts given;
参考文献
Munavalli, S.; Rossman, D. I.; Szafraniec, L. L.; Beaudry, W. T.; Rohrbaugh, D. K.; et al.
Journal of Fluorine Chemistry, 1995 , vol. 73, # 1 p. 1 - 6
