1-甲基-2-硝基-4-(三氟甲苯)甲苯合成路线 (共 8 条)
反应条件
potassium nitrate in sulfuric acid
参考文献
Kyorin Pharmaceutical Co., Ltd.
Patent: US6562839 B1, 2003 ;
US 6562839 B1
反应条件
HF in dichloromethane
反应条件
1: 1-amino-3-nitro-4-methylbenzene With hydrogenchloride in water T=0°C; 0.0833333 h; Inert atmosphereSchlenk technique; 2: With tert.-butylnitrite T=0°C; 0.25 h; Inert atmosphereSchlenk technique; 3: trifluoromethylsilver T=-78 - 20°C; 4 h; Inert atmosphereSchlenk technique;
参考文献
Journal of the American Chemical Society, , vol. 135, # 28 p. 10330 - 10333
反应条件
1: C13H20N4O2 With methyl iodide T=110°C; Inert atmosphere; 2: (trifluoromethyl)-trimethylsilane With potassium fluoride; copper(l) iodide in 1-methyl-pyrrolidin-2-one T=60°C; 16 h; Inert atmosphere;
参考文献
Hafner, Andreas; Braese, Stefan
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 5 p. 996 - 1000
反应条件
1: oxalic acid diethyl ester With sodium hydride in dimethyl sulfoxide T=100°C; 1 h; 2: 2-methyl-5-trifluoromethylnitrobenzene in dimethyl sulfoxide T=20 - 100°C; 1.5 h;
参考文献
US6878733 B1, ;
Page/Page column 171 ;
US 6878733 B1
反应条件
in hexane; dimethyl sulfoxide; ethyl acetate
参考文献
US6486185 B1, ;
US 6486185 B1
反应条件
palladium on charcoal in ethanol
参考文献
May and Baker Limited
Patent: US5206257 A1, 1993 ;