1-(4-氟苯基)-2-(4-吡啶基)乙酮合成路线 （共 17 条）
反应条件
sodium hexamethyldisilazane in tetrahydrofuran
参考文献
Rupert, Kenneth C.; Henry, James R.; Dodd, John H.; Wadsworth, Scott A.; Cavender, Druie E.; Olini, Gilbert C.; Fahmy, Bohumila; Siekierka, John J.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 347 - 350
反应条件
1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 0.0833333 h; 2: 4-Methylpyridine in tetrahydrofuran; hexane T=0°C; 0.25 h; 3: 4-fluoro-N-methoxy-N-methyl-benzamide in tetrahydrofuran; hexane T=0°C; 0.5 h;
参考文献
J. URIACH Y COMPANIA S.A.
Patent: WO2004/76450 A1, 2004 ;
Location in patent: Page 37-38 ;
WO 2004/076450 A1
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; hexane; water
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1402900 A1, 2004 ;
反应条件
lithium diisopropyl amide T=-78 - 20°C; 19 h;
参考文献
Seerden, Jean-Paul G.; Leusink-Ionescu, Gabriela; Leguijt, Robin; Saccavini, Catherine; Gelens, Edith; Dros, Bas; Woudenberg-Vrenken, Titia; Molema, Grietje; Kamps, Jan A.A.M.; Kellogg, Richard M.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 5 p. 1352 - 1357
反应条件
lithium diisopropyl amide in tetrahydrofuran; n-heptane
参考文献
US6528531 B1, ;
US6432980 B1, ;
反应条件
lithium diisopropyl amide in tetrahydrofuran; n-heptane
反应条件
n-butyllithium in tetrahydrofuran; hexane
参考文献
US5109002 A1, ;
US 5109002 A
反应条件
1.1: 100 percent / aq. NaOH / diethyl ether / 0 °C 2.1: LDA / tetrahydrofuran; hexane / 0.33 h / -10 °C 2.2: 56 percent / tetrahydrofuran; hexane / 1 h / -78 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 53, # 4 p. 410 - 418
参考文献
US5109002 A1, ;
US 5109002 A
反应条件
1: 4-Methylpyridine With lithium hexamethyldisilazane T=0°C; 0.5 h; 2: 4-Fluorobenzoic acid methyl ester
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 8 p. 2634 - 2638
