2,6-二氯-N-羟基-氯代苯甲醛肟合成路线 （共 21 条）
反应条件
sodium methylate in tetrahydrofuran T=20°C; 16 h;
参考文献
PHENEX PHARMACEUTICALS AG; KREMOSER, Claus; ABEL, Ulrich; STEENECK, Christoph; KINZEL, Olaf
Patent: WO2011/20615 A1, 2011 ;
Location in patent: Page/Page column 105 ;
反应条件
sodium methylate in methanol T=20°C;
参考文献
Chen, Weixuan; Huang, Ying-ju; Gundala, Sushma Reddy; Yang, Hsiuchin; Li, Minyong; Tai, Phang C.; Wang, Binghe
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 4 p. 1617 - 1625
反应条件
1: 4-methyl-3-oxopentanoic acid methyl ester With sodium methylate in tetrahydrofuran; methanol T=0°C; 2: 2,6-dichloro-N-hydroxybenzenecarboximidoyl chloride in tetrahydrofuran; methanol T=20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/48349 A1, 2004 ;
Location in patent: Page 46 ;
WO 2004/048349 A1
反应条件
1: With sodium methylate in tetrahydrofuran 2: With diisobutylaluminium hydride in tetrahydrofuran T=0 - 20°C;
参考文献
PHENEX PHARMACEUTICALS AG; KREMOSER, Claus; ABEL, Ulrich; STEENECK, Christoph; KINZEL, Olaf
Patent: WO2011/20615 A1, 2011 ;
反应条件
triethylamine; 3-phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-thione in dichloromethane T=20°C; Elimination; rearrangement; 48 h;
参考文献
Collins, David J.; Hughes, Timothy C.; Johnson, Wynona M.
Australian Journal of Chemistry, 2000 , vol. 53, # 2 p. 137 - 141
反应条件
triethylamine; 1-(2,6-Dichloro-phenyl)-3-phenyl-thiourea in tetrahydrofuran 0.5 h; Ambient temperature;
参考文献
Synthetic Communications, , vol. 28, # 10 p. 1879 - 1884
反应条件
triethylamine in tetrahydrofuran 0.166667 h; Ambient temperature; Yield given;
参考文献
Kim, Jae Nyoung; Jung, Keum Shin; Lee, Hong Jung; Son, Ji Suk
Tetrahedron Letters, 1997 , vol. 38, # 9 p. 1597 - 1598
反应条件
triethylamine in tetrahydrofuran T=20 - 67°C; 4 h;
参考文献
Easton; Heath; Hughes; Lee; Savage; Simpson; Tiekink; Vuckovic; Webster
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 10 p. 1168 - 1174
反应条件
triethylamine in tetrahydrofuran T=20°C; 7 h; Heating / reflux;
参考文献
RIGEL PHARMACEUTICALS, INC.
Patent: WO2005/82898 A1, 2005 ;
Location in patent: Page/Page column 62-63 ;
反应条件
triethylamine
Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2009/12125 A1, 2009 ;
Location in patent: Page/Page column 21 ;
