N-(2,3-二甲基苯基)-2-羟基亚氨基乙酰胺合成路线 （共 7 条）
反应条件
1: 86percent H2SO4 / 1) 55 deg C, 10 min, 2) 75 deg C, 30 min 2: H2O2, NaOH View Scheme
参考文献
Baker et al.
Journal of Organic Chemistry, 1952 , vol. 17, p. 149,153
反应条件
1: 65 percent / CH3SO3H / 70 - 80 °C 2: 65 percent / KOH, KCl, 27percent H2O2 / 20 °C 3: 1.) concd. H2SO4, NaNO2, 2.) KI / 1.) water, 10 deg C, 2.) 100 deg C 4: 63 percent / tris<2-(2-methoxyethoxy)ethyl>amine (TDA-1), CuCl / dimethylsulfoxide / 12 h / 95 °C 5: 70 percent / concd. H2SO4 / H2O / 0.17 h / 80 °C View Scheme
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Zhuang, Li; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 217 - 222
反应条件
1: 65 percent / CH3SO3H / 70 - 80 °C 2: 65 percent / KOH, KCl, 27percent H2O2 / 20 °C 3: 1.) concd. H2SO4, NaNO2, 2.) KI / 1.) water, 10 deg C, 2.) 100 deg C View Scheme
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Zhuang, Li; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 217 - 222
反应条件
methanesulfonic acid T=70 - 80°C; 1.25 h;
参考文献
US2008/255192 A1, ;
Page/Page column 15 ;
反应条件
1: 65 percent / CH3SO3H / 70 - 80 °C 2: 65 percent / KOH, KCl, 27percent H2O2 / 20 °C 3: 1.) concd. H2SO4, NaNO2, 2.) KI / 1.) water, 10 deg C, 2.) 100 deg C 4: 63 percent / tris<2-(2-methoxyethoxy)ethyl>amine (TDA-1), CuCl / dimethylsulfoxide / 12 h / 95 °C View Scheme
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Zhuang, Li; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 217 - 222
反应条件
hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate in water
T=45 - 75°C; 3.25 h;
参考文献
Wyeth
Patent: US2008/242700 A1, 2008 ;
Location in patent: Page/Page column 14 ;
反应条件
hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate
参考文献
Karnes,H.A. et al.
Journal of the American Chemical Society, 1965 , vol. 87, # 24 p. 5554 - 5558
