2,6-二氟-4-硝基苯酚合成路线 （共 10 条）
反应条件
nitric acid in acetic acid T=15 - 20°C;
参考文献
Qiu, Jian; Stevenson, Scott H.; O'Beirne, Michael J.; Silverman, Richard B.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 2 p. 329 - 332
反应条件
nitric acid in hexane; acetic acid
参考文献
Sankyo Company, Limited
Patent: US6555556 B1, 2003 ;
US 6555556 B1
反应条件
fluorine in formic acid T=0 - 10°C;
参考文献
Journal of Fluorine Chemistry, , vol. 128, # 1 p. 29 - 33
反应条件
1: 94 percent / K2CO3 / acetone / 6 h / Heating 2: 99 percent / H2 / 10 percent Pd/C / ethyl acetate View Scheme
参考文献
Kirk
Journal of Heterocyclic Chemistry, 1976 , vol. 13, # 6 p. 1253 - 1256
反应条件
4-tert-butyl-phenol; phosphorus pentachloride 1.) 130-140 deg C, 2 h, 2.) 230-240 deg C, 40 min;
参考文献
Cervera; Marquet; Martin
Tetrahedron, 1996 , vol. 52, # 7 p. 2557 - 2564
反应条件
potassium carbonate in acetone 6 h; Heating;
参考文献
Qiu, Jian; Stevenson, Scott H.; O'Beirne, Michael J.; Silverman, Richard B.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 2 p. 329 - 332
反应条件
1: 19 percent / PCl5, p-tert-butylphenol / 1.) 130-140 deg C, 2 h, 2.) 230-240 deg C, 40 min 2: 2 percent / methanol / 2 h / Ambient temperature View Scheme
参考文献
Cervera; Marquet; Martin
Tetrahedron, 1996 , vol. 52, # 7 p. 2557 - 2564
参考文献
Kirk
Journal of Heterocyclic Chemistry, 1976 , vol. 13, # 6 p. 1253 - 1256
反应条件
hydrogen; palladium on activated charcoal in ethanol 2 h;
参考文献
SmithKline Beckman Intercredit B.V.
Patent: US5143920 A1, 1992 ;
反应条件
1: 94 percent / K2CO3 / acetone / 6 h / Heating 2: 99 percent / H2 / 10 percent Pd/C / ethyl acetate 3: 64 percent / I2, aq. NaHCO3 / Ambient temperature 4: 1.) aq. NaNO2, H2SO4, 2.) Cu / 1.) 0 deg C, 30 min, 2.) EtOH, from 60 deg C to 75 deg C, 3 h 5: 83 percent / dimethylformamide / 22 h / 120 - 140 °C View Scheme
参考文献
Qiu, Jian; Stevenson, Scott H.; O'Beirne, Michael J.; Silverman, Richard B.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 2 p. 329 - 332
