2-(3-氯-5-(三氟甲基)吡啶-2-基)乙胺合成路线 （共 4 条）
反应条件
hydrogen; palladium on activated carbon in acetic acid
T=20°C; P=4500.45 Torr; 15 h; Product distribution / selectivity;
参考文献
Bayer CropScience S.A.
Patent: EP1674455 A1, 2006 ;
Location in patent: Page/Page column 17 ;
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C
1.2: 0 - 20 °C
2.1: hydrogen bromide; acetic acid / 3.5 h / 110 °C
3.1: hydrazine hydrate / ethanol / 3 h / 80 °C
View Scheme
参考文献
Fodor, Elena; Maftei, Catalin-Vasile; Mangalagiu, Ionel; Jones, Peter G.; Daniliuc, Constantin-Gabriel; Franz, M. Heiko; Neda, Ion
Revue Roumaine de Chimie, 2010 , vol. 55, # 9 p. 559 - 564
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C
1.2: 0 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C
2.2: 0 - 20 °C
3.1: hydrogen bromide; acetic acid / 3.5 h / 110 °C
4.1: hydrazine hydrate / ethanol / 3 h / 80 °C
View Scheme
参考文献
Fodor, Elena; Maftei, Catalin-Vasile; Mangalagiu, Ionel; Jones, Peter G.; Daniliuc, Constantin-Gabriel; Franz, M. Heiko; Neda, Ion
Revue Roumaine de Chimie, 2010 , vol. 55, # 9 p. 559 - 564
反应条件
sodium hydroxide in tetrahydrofuran; water
pH=8; 1 h;
参考文献
Bayer CropScience S.A.
Patent: EP1674455 A1, 2006 ;
Location in patent: Page/Page column 17 ;
