N-[[[4-氯-2-(2-氯苯甲酰基)苯基]-甲基-氨基甲酰]甲基]十六烷酰胺合成路线 （共 3 条）
反应条件
in N,N-dimethyl-formamide
3.5 h; Ambient temperature;
参考文献
Hirai, Kentaro; Ishiba, Teruyuki; Sugimoto, Hirohiko; Fujishita, Toshio; Tsukinoki, Yuji; Hirose, Katsumi
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 20 - 27
反应条件
1: 1.) NaH / 1.) DMF, oil, 2-5 deg C, 15 min, 2.) DMF, oil, 2-5 deg C, 2 h
2: 97 percent / 20percent HBr / acetic acid / 1 h / Ambient temperature
3: 45.5 percent / dimethylformamide / 3.5 h / Ambient temperature
View Scheme
参考文献
Hirai, Kentaro; Ishiba, Teruyuki; Sugimoto, Hirohiko; Fujishita, Toshio; Tsukinoki, Yuji; Hirose, Katsumi
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 20 - 27
反应条件
1: 97 percent / 20percent HBr / acetic acid / 1 h / Ambient temperature
2: 45.5 percent / dimethylformamide / 3.5 h / Ambient temperature
View Scheme
参考文献
Hirai, Kentaro; Ishiba, Teruyuki; Sugimoto, Hirohiko; Fujishita, Toshio; Tsukinoki, Yuji; Hirose, Katsumi
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 20 - 27
