4-氯-5-(1-甲基乙基)-吡咯并[2,1-f][1,2,4]噻嗪-6-羧酸乙酯合成路线 （共 6 条）
反应条件
trichlorophosphate T=110°C; 3 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2004/13145 A1, 2004 ;
Location in patent: Page 30 ;
WO 2004/013145 A1
反应条件
1: O-(diphenylphosphinyl)-hydroxylamine; NaH / dimethylformamide 2: 87 percent / 165 °C 3: POCl3 / 100 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 21 p. 4774 - 4779
反应条件
1: 87 percent / 165 °C 2: POCl3 / 100 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 21 p. 4774 - 4779
反应条件
1: DBU / tetrahydrofuran / 50 °C 2: O-(diphenylphosphinyl)-hydroxylamine; NaH / dimethylformamide 3: 87 percent / 165 °C 4: POCl3 / 100 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 21 p. 4774 - 4779
反应条件
1: AlCl3 2: NaOMe 3: Ph2P(O)ONH2; NaH / dimethylformamide 4: Heating 5: POCl3 / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 5 p. 1429 - 1433
反应条件
1: sodium hydride / tetrahydrofuran; dimethylsulfoxide 2: AlCl3 3: NaOMe 4: Ph2P(O)ONH2; NaH / dimethylformamide 5: Heating 6: POCl3 / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 5 p. 1429 - 1433
