piperidine T=110°C;

1: 3 h / 100 °C 2: 1.) 4-(hydroxymethyl)phenoxyacetic acid, HOBt, DIPCDI, (aminomethyl)polystyrene, 2.) CBr4, PPh3, 3.) <(CH3)3SiNK, 4.) NaOMe, 5.) TFA / 1.) CH2Cl2, DMF, overnight, 2.) CH2Cl2, 0 deg C, 3.) DMF, overnight, 4.) DMF, overnight, 5.) H2O, 2 h View Scheme

(aminomethyl)polystyrene; carbon tetrabromide; Di-tert-butylcarbodiimide; sodium methylate; potassium hexamethylsilazane; benzotriazol-1-ol; 4-hydroxymethyl-phenoxy acetic acid; triphenylphosphine; trifluoroacetic acid 1.) CH2Cl2, DMF, overnight, 2.) CH2Cl2, 0 deg C, 3.) DMF, overnight, 4.) DMF, overnight, 5.) H2O, 2 h; Yield given. Multistep reaction;