1-（3,4-二氯苯基）-1-丙酮合成路线 （共 10 条）
反应条件
1: 1,2-dichloro-benzene With AlCl3, aluminium chloride in dichloromethane T=20°C; 0.166667 h; 2: propionic acid anhydride in dichloromethane T=0°C; Friedel-Crafts acylation; 1 h;
参考文献
Zheng, Yong-Yong; Guo, Lin; Zhen, Xue-Chu; Li, Jian-Qi
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 123 - 136
参考文献
Journal of Organic Chemistry, , vol. 41, p. 2368 - 2372
反应条件
1: 1.) SOCl2, 2.) NH4OH, 3.) SOCl2 / 2.) dioxane, 3.) reflux 2: ethanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 1 p. 1 - 6
反应条件
2: H2CrO4 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 41, p. 2368 - 2372
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 1 p. 1 - 6
反应条件
aluminium trichloride
参考文献
Pharmazie, , vol. 22, p. 19 - 22
Journal of the Karnatak University, , vol. 1, p. 39,41, 42
反应条件
1: Grignard reaction; Inert atmosphere; 2: With water
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 12 p. 4731 - 4748
参考文献
Devasthale et al.
Journal of the Karnatak University, 1956 , vol. 1, p. 39,41, 42
反应条件
1: With bromine in methanol
T=20°C; 0.166667 h;
2: With hydrogen bromide in methanol; water
110 h; Inert atmosphere;
参考文献
RESEARCH TRIANGLE INSTITUTE; CARROLL, Frank Ivy; BLOUGH, Bruce; ABRAHAM, Philip
Patent: WO2010/121022 A1, 2010 ;
Location in patent: Page/Page column 70 ;
WO 2010/121022 A1
反应条件
1: With sodium hydride in ethanol; benzene
2.25 h;
2: With hydrogen bromide; acetic acid in water
Heating;
参考文献
Meza-Toledo, Sergio Enrique; Olea-Gomez, Arturo; Mora-Ramirez, Erika Y.; Peralta-Cruz, Javier; Nogueron-Chirinos, Jaisel B.
Arzneimittel-Forschung/Drug Research, 2004 , vol. 54, # 12 p. 830 - 834
