您好，欢迎来到魔法化学网！
合作交流
|
服务时间(9:30-18:00)
百科
百科
▼
百科
资讯
搜索
结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
首页
化合物百科
价格行情
资讯
化工导航
实验室工具
搜索
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
4'-氯代新戊酰苯胺
合成路线
（共 29 条）
383-63-1
三氟乙酸乙酯
+
65854-91-3
4'-氯代新戊酰苯胺
→
反应条件
1184936-21-7
2-(三氟乙酰基)-4-氯苯胺盐酸盐水合物
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine; acetic acid in hydrogenchloride; hexane; tert-butyl methyl ether
参考文献
DuPont Pharmaceuticals Company
Patent: US6028237 A1, 2000 ;
65854-91-3
4'-氯代新戊酰苯胺
→
反应条件
116278-66-1
反应条件
dipotassium peroxodisulfate; [Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2; trifluoroacetic acid; trifluoroacetic anhydride T=80°C; Sealed tube; regioselective reaction;
参考文献
Yang, Xinglin; Shan, Gang; Rao, Yu
Organic Letters, 2013 , vol. 15, # 10 p. 2334 - 2337
500-22-1
3-吡啶甲醛
+
65854-91-3
4'-氯代新戊酰苯胺
→
反应条件
114995-53-8
反应条件
Multistep reaction;
参考文献
Kyba, Evan P.; Liu, Shiuh-Tzung; Chockalingam, Kannappan; Reddy, B. Raghava
Journal of Organic Chemistry, 1988 , vol. 53, # 15 p. 3513 - 3521
65854-91-3
4'-氯代新戊酰苯胺
→
反应条件
698394-73-9
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -30 - -20 °C / |Inert atmosphere 1.2: 4 h / 15 - 25 °C / |Inert atmosphere 1.3: 4 h / 55 - 65 °C 2.1: pyridine; 4-(N,N-dimethlyamino)pyridine / 24 h / 60 - 75 °C 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16.5 h / 0 - 20 °C View Scheme
参考文献
Takeda Pharmaceutical Company Limited; Suzuki, Nobutaka; Miyazaki, Takahiro; Ochi, Takashi
Patent: US2014/155437 A1, 2014 ;
65854-91-3
4'-氯代新戊酰苯胺
→
反应条件
84060-24-2
反应条件
1: 45.4 percent / n-butyllithium / hexane; tetrahydrofuran / -5 °C 2: 62.4 percent / 3 N H2SO4 / H2O / 16 h / Heating 3: pyridine / 0 °C 4: aq. NaOH / methanol 5: 85.5 percent / hydrogen, 1N HCl / 10percent Pd-C / H2O; methanol / 20 h / 40 °C 6: 86.3 percent / TEA / ethanol / Ambient temperature 7: 97.7 percent / NaBH4 / ethanol / 72 h / Ambient temperature View Scheme
参考文献
Takai; Obase; Teranishi; Karasawa; Kubo; Shuto; Kasuya; Hashikami; Karashima; Shigenobu
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1129 - 1139
65854-91-3
4'-氯代新戊酰苯胺
→
反应条件
85732-25-8
反应条件
1: 45.4 percent / n-butyllithium / hexane; tetrahydrofuran / -5 °C 2: 62.4 percent / 3 N H2SO4 / H2O / 16 h / Heating 3: pyridine / 0 °C 4: aq. NaOH / methanol 5: 85.5 percent / hydrogen, 1N HCl / 10percent Pd-C / H2O; methanol / 20 h / 40 °C 6: 93.2 percent / TEA / ethanol / Ambient temperature 7: 91.9 percent / NaBH4 / ethanol / 72 h / Ambient temperature View Scheme
参考文献
Takai; Obase; Teranishi; Karasawa; Kubo; Shuto; Kasuya; Hashikami; Karashima; Shigenobu
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1129 - 1139
65854-91-3
4'-氯代新戊酰苯胺
→
反应条件
85732-29-2
反应条件
1: 45.4 percent / n-butyllithium / hexane; tetrahydrofuran / -5 °C 2: 62.4 percent / 3 N H2SO4 / H2O / 16 h / Heating 3: pyridine / 0 °C 4: aq. NaOH / methanol 5: 85.4 percent / diethyl ether; 1,2-dichloro-ethane / 1 h / Ambient temperature 6: 84.9 percent / 3.52 N HCl (in ethyl acetate) / CH2Cl2 / 1.5 h / Ambient temperature 7: 85.5 percent / TEA / ethanol / Ambient temperature 8: 88.6 percent / NaBH4 / ethanol / 72 h / Ambient temperature View Scheme
参考文献
Takai; Obase; Teranishi; Karasawa; Kubo; Shuto; Kasuya; Hashikami; Karashima; Shigenobu
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1129 - 1139
65854-91-3
4'-氯代新戊酰苯胺
→
反应条件
85732-37-2
反应条件
1: 45.4 percent / n-butyllithium / hexane; tetrahydrofuran / -5 °C 2: 62.4 percent / 3 N H2SO4 / H2O / 16 h / Heating 3: pyridine / 0 °C 4: aq. NaOH / methanol 5: 85.5 percent / hydrogen, 1N HCl / 10percent Pd-C / H2O; methanol / 20 h / 40 °C View Scheme
参考文献
Takai; Obase; Teranishi; Karasawa; Kubo; Shuto; Kasuya; Hashikami; Karashima; Shigenobu
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1129 - 1139
65854-91-3
4'-氯代新戊酰苯胺
→
反应条件
85732-70-3
反应条件
1: 45.4 percent / n-butyllithium / hexane; tetrahydrofuran / -5 °C 2: 62.4 percent / 3 N H2SO4 / H2O / 16 h / Heating View Scheme
参考文献
Takai; Obase; Teranishi; Karasawa; Kubo; Shuto; Kasuya; Hashikami; Karashima; Shigenobu
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1129 - 1139
首页
上一页
1
2
3
到第
页
确定
