N-(2-溴苯基)-2,2-二甲基丙酰胺合成路线 （共 14 条）
反应条件
1: 1.)MeLi/ether, t-BuLi / 1.) THF, pentane, -78 deg C, 1 h; 2.) -10 deg C, 30 min, then ambient temp., 30 min 2: 93 percent / t-BuOK, H2O / tetrahydrofuran / 0.17 h / Ambient temperature View Scheme
参考文献
Wender, Paul A.; White, Alan W.
Tetrahedron Letters, 1981 , vol. 22, # 16 p. 1475 - 1478
反应条件
Yield given. Multistep reaction;
参考文献
Wender, Paul A.; White, Alan W.
Tetrahedron Letters, 1981 , vol. 22, # 16 p. 1475 - 1478
反应条件
diethyl ether; methyllithium; tert.-butyl lithium 1.) THF, pentane, -78 deg C, 1 h; 2.) -78 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Wender, Paul A.; White, Alan W.
Tetrahedron Letters, 1981 , vol. 22, # 16 p. 1475 - 1478
反应条件
palladium diacetate; silver carbonate T=125°C; 16 h;
参考文献
Mousseau, James J.; Vallee, Frederic; Lorion, Melanie M.; Charette, Andre B.
Journal of the American Chemical Society, 2010 , vol. 132, # 41 p. 14412 - 14414
反应条件
n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran T=-70 - -60°C; 6.08333 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2009/61875 A2, 2009 ;
Location in patent: Page/Page column 38-39 ;
反应条件
1: N-(2-bromophenyl)-2,2-dimethylpropionamide With n-butyllithium in tetrahydrofuran T=-70 - -60°C; 1.75 h; 2: 2-isopropyl borate in tetrahydrofuran T=-70 - -60°C; 4.33 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; MACIKENAS, Dainius
Patent: WO2009/76200 A2, 2009 ;
Location in patent: Page/Page column 58 ;
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran
参考文献
E.I. DU PONT DE NEMOURS AND COMPANY
Patent: EP619804 B1, 1996 ;
反应条件
in ethyl acetate
T=85°C;
参考文献
Zheng, Nan; Anderson, Kevin W.; Huang, Xiaohua; Nguyen, Hanh Nho; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2007 , vol. 46, # 39 p. 7509 - 7512
反应条件
N-bromosuccinmide; palladium diacetate; toluene-4-sulfonic acid in toluene
T=20°C; 4 h;
参考文献
Bedford, Robin B.; Haddow, Mairi F.; Mitchell, Charlotte J.; Webster, Ruth L.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 24 p. 5524 - 5527
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C
2: N-bromosuccinmide; palladium diacetate; toluene-4-sulfonic acid / toluene / 4 h / 20 °C
View Scheme
参考文献
Bedford, Robin B.; Haddow, Mairi F.; Mitchell, Charlotte J.; Webster, Ruth L.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 24 p. 5524 - 5527
