6-甲氧基-3-吡啶甲醛合成路线 （共 32 条）
反应条件
1: 2-methoxy-5-bromo-pyridine With n-butyllithium; isopropylmagnesium chloride in tetrahydrofuran; hexane T=-2 - 0°C; 0.75 h; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=0 - 20°C; Inert atmosphere;
参考文献
Struk, Lukasz; Sosnicki, Jacek G.
Synthesis, 2012 , vol. 44, # 5 p. 735 - 746
反应条件
formaldehyd; sodium acetate; nickel monoaluminide in hydrogenchloride; ethanol; water
参考文献
Smith Kline and French Laboratories Limited
Patent: US4234588 A1, 1980 ;
反应条件
n-butyllithium in tetrahydrofuran; N-methyl-acetamide
参考文献
Baxter, Andrew; Brough, Stephen; Faull, Alan; Johnstone, Craig; McInally, Thomas
Patent: US2002/107252 A1, 2002 ;
反应条件
manganese(IV) oxide in chloroform 0.0833333 h; Ambient temperature;
参考文献
Yamano, Kimiaki; Shirahama, Haruhisa
Tetrahedron, 1992 , vol. 48, # 8 p. 1457 - 1464
反应条件
n-butyllithium; ammonium chloride in N,N-dimethyl-formamide
反应条件
bromine; sodium acetate in hexane; acetic acid
参考文献
Baxter, Andrew; Brough, Stephen; Faull, Alan; Johnstone, Craig; McInally, Thomas
Patent: US2002/107252 A1, 2002 ;
反应条件
hydrogenchloride in tetrahydrofuran 0.0833333 h;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 283 - 287
反应条件
hydrogenchloride; sodium hydroxide in methanol; water; ethyl acetate
反应条件
1: 80 percent / methanol / 16 h / Heating 2: nBuLi / tetrahydrofuran / -78 deg C, 180 min, -78 deg C to rt View Scheme
参考文献
Journal of the American Chemical Society, , vol. 119, # 33 p. 7694 - 7701
反应条件
hydrogenchloride; formaldehyd; hydrogen; semicarbazide-hydrochloride; sodium acetate; nickel 1.) EtOH, H2O, 50 psi, 2.) EtOH, H2O, heating, 15 min; Yield given. Multistep reaction;
参考文献
European Journal of Medicinal Chemistry, , vol. 28, # 7-8 p. 601 - 608
