6-甲氧基-3-吡啶甲醛合成路线 （共 32 条）
反应条件
1: 83 percent / DIBAH / CH2Cl2; hexane / 0.17 h / -20 °C 2: 99 percent / MnO2 / CHCl3 / 0.08 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 48, # 8 p. 1457 - 1464
反应条件
1: 64 percent / phosphorus pentachloride / 72 h / 115 °C 2: 80 percent / tetrahydrofuran-d8 / 48 h / Ambient temperature; in a dry box 3: 60 percent / sodium / 4 h / Heating 4: concentrated aq. HCl / tetrahydrofuran / 0.08 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 283 - 287
反应条件
1: 80 percent / tetrahydrofuran-d8 / 48 h / Ambient temperature; in a dry box 2: 60 percent / sodium / 4 h / Heating 3: concentrated aq. HCl / tetrahydrofuran / 0.08 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 283 - 287
反应条件
1: 60 percent / sodium / 4 h / Heating 2: concentrated aq. HCl / tetrahydrofuran / 0.08 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 283 - 287
反应条件
1.1: N-bromosuccinmide / acetonitrile / 20 h / Reflux 2.1: n-butyllithium; isopropylmagnesium chloride / tetrahydrofuran; hexane / 0.75 h / -2 - 0 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Synthesis, , vol. 44, # 5 p. 735 - 746
反应条件
manganese; titanium tetrachloride in tetrahydrofuran T=-10°C; 0.666667 h; Inert atmosphere; optical yield given as percent de;
参考文献
Duan, Xin-Fang; Feng, Jian-Xia; Zi, Guo-Fu; Zhang, Zhan-Bin
Synthesis, 2009 , # 2 p. 277 - 282
反应条件
manganese; titanium tetrachloride in tetrahydrofuran T=-10°C; 0.666667 h; Inert atmosphere; optical yield given as percent de;
参考文献
Duan, Xin-Fang; Feng, Jian-Xia; Zi, Guo-Fu; Zhang, Zhan-Bin
Synthesis, 2009 , # 2 p. 277 - 282
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 2: With water; ethyl acetate in toluene
参考文献
JANSSEN PHARMACEUTICA N.V.; ADDEX PHARMACEUTICALS S.A.
Patent: WO2006/30032 A1, 2006 ;
Location in patent: Page/Page column 104-105 ;
WO 2006/030032 A1
反应条件
manganese; titanium tetrachloride in tetrahydrofuran T=-10°C; 0.666667 h; Inert atmosphere; optical yield given as percent de;
参考文献
Duan, Xin-Fang; Feng, Jian-Xia; Zi, Guo-Fu; Zhang, Zhan-Bin
Synthesis, 2009 , # 2 p. 277 - 282
反应条件
manganese; titanium tetrachloride in tetrahydrofuran T=-10°C; 0.666667 h; Inert atmosphere; optical yield given as percent de;
参考文献
Duan, Xin-Fang; Feng, Jian-Xia; Zi, Guo-Fu; Zhang, Zhan-Bin
Synthesis, 2009 , # 2 p. 277 - 282
