4,5,6,7-四氢异吲哚-1-羧酸乙酯合成路线 （共 12 条）
反应条件
P(MeNCH2CH2)3N in tetrahydrofuran
T=-20 - -15°C; 2 h;
参考文献
Donohoe; Raoof; Linney; Helliwell
Organic letters, 2001 , vol. 3, # 6 p. 861 - 864
反应条件
potassium tert-butylate in tetrahydrofuran
T=0°C;
参考文献
Finikova; Chernov; Cheprakov; Filatov; Vinogradov; Beletskaya
Doklady Chemistry, 2003 , vol. 391, # 4-6 p. 222 - 224
反应条件
1: With 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran
T=0 - 20°C; 60 h;
2: With hydrogenchloride in tetrahydrofuran; water
Cooling with ice;
参考文献
KARO BIO AB; HAGBERG, Lars; NOeTEBERG, Daniel
Patent: WO2012/136772 A1, 2012 ;
Location in patent: Page/Page column 51-51 ;
WO 2012/136772 A1
反应条件
sodium ethanolate in ethanol
3 h; Heating;
参考文献
Hombrecher, Hermann K.; Horter, Gaby
Synthesis, 1990 , # 5 p. 389 - 391
反应条件
sodium hydride in tetrahydrofuran
2 h; Ambient temperature;
参考文献
Arnold, Dennis P.; Burgess-Dean, Leon; Hubbard, Jason; Rahman, M. Abdur
Australian Journal of Chemistry, 1994 , vol. 47, # 5 p. 969 - 974
反应条件
1: MCPBA / CH2Cl2 / 20 °C
2: triethylamine
3: 90 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
View Scheme
参考文献
Finikova, Olga S.; Cheprakov, Andrei V.; Beletskaya, Irina P.; Carroll, Patrick J.; Vinogradov, Sergei A.
Journal of Organic Chemistry, 2004 , vol. 69, # 2 p. 522 - 535
反应条件
1: triethylamine
2: 90 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
View Scheme
参考文献
Finikova, Olga S.; Cheprakov, Andrei V.; Beletskaya, Irina P.; Carroll, Patrick J.; Vinogradov, Sergei A.
Journal of Organic Chemistry, 2004 , vol. 69, # 2 p. 522 - 535
反应条件
1: CH2Cl2 / 20 °C
2: MCPBA / CH2Cl2 / 20 °C
3: triethylamine
4: 90 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
View Scheme
参考文献
Finikova, Olga S.; Cheprakov, Andrei V.; Beletskaya, Irina P.; Carroll, Patrick J.; Vinogradov, Sergei A.
Journal of Organic Chemistry, 2004 , vol. 69, # 2 p. 522 - 535
反应条件
1: 53 percent / NEt3 / ethanol / 15 h / Ambient temperature
2: 42 percent / NaOEt / ethanol / 3 h / Heating
View Scheme
参考文献
Hombrecher, Hermann K.; Horter, Gaby
Synthesis, 1990 , # 5 p. 389 - 391
反应条件
1: 1,8-diazabicyclo[5.6.0]undec-7-ene / CH2Cl2 / 20 °C
2: 95 percent / t-BuOK / tetrahydrofuran / 0 °C
View Scheme
参考文献
Finikova; Chernov; Cheprakov; Filatov; Vinogradov; Beletskaya
Doklady Chemistry, 2003 , vol. 391, # 4-6 p. 222 - 224
