2-氨基-3-氧代丁酸乙酯合成路线 （共 10 条）
反应条件
hydrogenchloride; palladium on activated charcoal
Hydrogenation;
参考文献
McIlwain; Richardson
Biochemical Journal, 1939 , vol. 33, p. 44
Full Text Show Details
Kondo; Ohno
Yakugaku Zasshi, 1934 , vol. 54, p. 683,687; dtsch. Ref. S. 123
Chem.Abstr., 1937 , p. 103
反应条件
sulfuric acid; zinc
T=0°C; 0.5 h;
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
hydrogenchloride in 1,4-dioxane
参考文献
Nemoto, Tetsuhiro; Harada, Teisuke; Matsumoto, Takayoshi; Hamada, Yasumasa
Tetrahedron Letters, 2007 , vol. 48, # 36 p. 6304 - 6307
反应条件
1.) LiHNDS
1.) THF, -78 deg C, 45 min, 2.) THF, RT, 4 h; Multistep reaction;
参考文献
Von Geldern, Thomas W.; Hutchins, Charles; Kester, Jeffrey A.; Wu-Wong, Jinshyun R.; Chiou, William; Dixon, Douglas B.; Opgenorth, Terry J.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 957 - 967
反应条件
potassium chloride; N-hexadecyl-N,N,N-trimethylammonium bromide in methanol
T=30°C; polarographic reduction at pH=6.0 (Britton-Robinson buffer); Equilibrium constantMechanism;
参考文献
Malik, Wahid U.; Jain, Rajeev
Journal of the Indian Chemical Society, 1982 , vol. 59, # 2 p. 191 - 194
参考文献
Druzgala, Pascal; Milner, Peter G.; Pfister, Jurg R.
Patent: US2003/236227 A1, 2003 ;
Location in patent: Page 3; sheet 25 ;
US 20030236227 A1
参考文献
McIlwain; Richardson
Biochemical Journal, 1939 , vol. 33, p. 44
Full Text Show Details
Kondo; Ohno
Yakugaku Zasshi, 1934 , vol. 54, p. 683,687; dtsch. Ref. S. 123
Chem.Abstr., 1937 , p. 103
参考文献
Scheiber; Haun
Chemische Berichte, 1914 , vol. 47, p. 3338
反应条件
sodium acetate in water
T=20°C; 24 h;
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
in tetrahydrofuran
24 h; Ambient temperature; Yield given;
参考文献
Nemoto, Tetsuhiro; Harada, Teisuke; Matsumoto, Takayoshi; Hamada, Yasumasa
Tetrahedron Letters, 2007 , vol. 48, # 36 p. 6304 - 6307
