1-甲烷磺酰基-11-羟基-3,6,9-三氧杂十一烷合成路线 （共 16 条）
反应条件
1.1: 94 percent / sodium azide / dimethylformamide / 2.5 h / 110 °C 2.1: 92 percent / Et3N / CH2Cl2 / 0.83 h / 0 - 20 °C 3.1: NaH / dimethylformamide / 0.5 h / 20 °C 3.2: dimethylformamide / 22 h / 20 °C 4.1: 0.51 g / p-TsOH / methanol View Scheme
参考文献
Svedhem; Hollander; Shi; Konradsson; Liedberg; Svensson
Journal of Organic Chemistry, 2001 , vol. 66, # 13 p. 4494 - 4503
反应条件
1.1: 94 percent / sodium azide / dimethylformamide / 2.5 h / 110 °C 2.1: Ph3P / tetrahydrofuran / 10 h / 20 °C 2.2: 99 percent / H2O / tetrahydrofuran View Scheme
参考文献
Leal, Manuel Pernia; Assali, Mohyeddin; Fernandez, Inmaculada; Khiar, Noureddine
Chemistry - A European Journal, 2011 , vol. 17, # 6 p. 1828 - 1836
反应条件
sodium azide in ethanol Reflux;
参考文献
Leal, Manuel Pernia; Assali, Mohyeddin; Fernandez, Inmaculada; Khiar, Noureddine
Chemistry - A European Journal, 2011 , vol. 17, # 6 p. 1828 - 1836
反应条件
1: 85 percent / NaN3 / acetonitrile / 36 h / Heating 2: 100 percent / triphenylphosphine, H2O / tetrahydrofuran / 4 h / Ambient temperature 3: 90 percent / KOH / H2O; dioxane / 1) 0 deg C, 1 h, 2) room temp., 4 h View Scheme
参考文献
Pokorski, Jonathan K.; Breitenkamp, Kurt; Liepold, Lars O.; Qazi, Shefah; Finn
Journal of the American Chemical Society, 2011 , vol. 133, # 24 p. 9242 - 9245
反应条件
1: sodium azide / N,N-dimethyl-formamide / 12 h / 65 °C 2: triethylamine / dichloromethane / 3.5 h / 0 - 20 °C 3: N,N-dimethyl-formamide / 15 h / 110 °C 4: hydrazine / ethanol / 3 h / 60 °C View Scheme
参考文献
Goswami, Lalit N.; Houston, Zachary H.; Sarma, Saurav J.; Jalisatgi, Satish S.; Hawthorne, M. Frederick
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1116 - 1126
反应条件
1.1: 94 percent / sodium azide / dimethylformamide / 2.5 h / 110 °C 2.1: 92 percent / Et3N / CH2Cl2 / 0.83 h / 0 - 20 °C 3.1: NaH / dimethylformamide / 0.5 h / 20 °C 3.2: dimethylformamide / 22 h / 20 °C 4.1: 0.51 g / p-TsOH / methanol 5.1: Ph3P / tetrahydrofuran / 20 h / 20 °C 5.2: 90 percent / H2O / tetrahydrofuran View Scheme
参考文献
Svedhem; Hollander; Shi; Konradsson; Liedberg; Svensson
Journal of Organic Chemistry, 2001 , vol. 66, # 13 p. 4494 - 4503
反应条件
1: NaN3 / ethanol / Heating 2: 80 percent / CrO3; aq. H2SO4 / acetone View Scheme
参考文献
Leal, Manuel Pernia; Assali, Mohyeddin; Fernandez, Inmaculada; Khiar, Noureddine
Chemistry - A European Journal, 2011 , vol. 17, # 6 p. 1828 - 1836
反应条件
1: NaN3 / ethanol / Heating 2: 80 percent / CrO3; aq. H2SO4 / acetone 3: 100 percent / H2 / Pd/C / ethanol View Scheme
参考文献
Nakatani, Kazuhiko; Kobori, Akio; Kumasawa, Hiroyuki; Saito, Isao
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 5 p. 1105 - 1108
反应条件
triethylamine in tetrahydrofuran
T=0°C; 1.5 h;
参考文献
Zemlyakov; Kur'yanov; Sidorova; Chupakina; Chirva
Chemistry of Natural Compounds, 1997 , vol. 33, # 5 p. 563 - 567
反应条件
silver(l) oxide in dichloromethane
48 h;
参考文献
Svedhem; Hollander; Shi; Konradsson; Liedberg; Svensson
Journal of Organic Chemistry, 2001 , vol. 66, # 13 p. 4494 - 4503
