1: 2,5-dimethoxy-tetrahydrofuran With hydrogenchloride in water
T=0°C;
2: acetone-1,3-dicarboxylic acid; 4-fluorobenzenemethanamine hydrochloride With sodium acetate in water
T=20 - 50°C; 3.5 h;
3: With sodium hydroxide in water
T=0°C; pH=10;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2004/9588 A1, 2004 ;
Location in patent: Page 48 ;
WO 2004/009588 A1