2-(3-吡啶基)-1,3,4-恶二唑合成路线 （共 6 条）
反应条件
hydrazine hydrate in ethanol
T=140°C; Sealed tube;
参考文献
Zou, Liang-Hua; Reball, Jens; Mottweiler, Jakob; Bolm, Carsten
Chemical Communications (Cambridge, United Kingdom), 2012 , vol. 48, # 92 p. 11307 - 11309,3
反应条件
1: sulfuric acid / 10 h / |Reflux; |Sealed tube
2: hydrazine hydrate / ethanol / |Reflux; |Sealed tube
3: hydrazine hydrate / ethanol / 140 °C / |Sealed tube
View Scheme
参考文献
Zou, Liang-Hua; Reball, Jens; Mottweiler, Jakob; Bolm, Carsten
Chemical Communications (Cambridge, United Kingdom), 2012 , vol. 48, # 92 p. 11307 - 11309,3
反应条件
1: hydrazine hydrate / ethanol / |Reflux; |Sealed tube
2: hydrazine hydrate / ethanol / 140 °C / |Sealed tube
View Scheme
参考文献
Zou, Liang-Hua; Reball, Jens; Mottweiler, Jakob; Bolm, Carsten
Chemical Communications (Cambridge, United Kingdom), 2012 , vol. 48, # 92 p. 11307 - 11309,3
反应条件
orthoformic acid triethyl ester
参考文献
Ainsworth
Journal of the American Chemical Society, 1955 , vol. 77, p. 1148
反应条件
toluene-4-sulfonic acid
T=80 - 120°C;
参考文献
Ohmoto; Yamamoto; Okuma; Horiuchi; Imanishi; Odagaki; Kawabata; Sekioka; Hirota; Matsuoka; Nakai; Toda; Cheronis; Spruce; Gyorkos; Wieczorek
Journal of Medicinal Chemistry, 2001 , vol. 44, # 8 p. 1268 - 1285
反应条件
diphosphorus pentasulfide in sodium hydroxide; anhydrous xylene; ethanol; chloroform; water
参考文献
Ciba-Geigy Corporation
Patent: US4892880 A1, 1990 ;
