5-氨基-1-(2-硝基苯基)-1H-吡唑-4-甲腈合成路线 （共 6 条）
参考文献
Bayer HealthCare AG
Patent: US2007/161662 A1, 2007 ;
反应条件
in ethanol
3 h; Heating;
参考文献
Peet; Sunder; Barbuch
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 3 p. 511 - 514
反应条件
acetic acid in ethanol
1 h; Heating;
参考文献
Costanzo; Bruni; Guerrini; Selleri; Malmberg Aiello; Lamberti
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 6 p. 1499 - 1505
反应条件
1: 1.) NaNO2, HCl, 2.) SnCl2, HCl / 1.) H2O, 0 deg C, 2.) H2O, RT, 1 h
2: 33 percent / ethanol / 1 h / Heating
View Scheme
参考文献
Harden; Quinn; Scammells
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2892 - 2898
反应条件
1: 52 percent / ethanol; H2O / 0.5 h / Heating
2: 50 percent / acetic acid / aq. ethanol / 1 h / Heating
View Scheme
参考文献
Costanzo; Bruni; Guerrini; Selleri; Malmberg Aiello; Lamberti
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 6 p. 1499 - 1505
参考文献
Harden; Quinn; Scammells
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2892 - 2898
