5-氨基-1-(3-硝基苯基)-1H-吡唑-4-甲腈合成路线 （共 7 条）
反应条件
1: 3-Nitrophenylhydrazine hydrochloride With N-ethyl-N,N-diisopropylamine in ethanol
T=20°C; 2 h;
2: (ethoxymethylene)malononitrile in ethanol
1 h; Heating / reflux;
参考文献
Nuevolution A/S
Patent: WO2009/152824 A1, 2009 ;
Location in patent: Page/Page column 219-220 ;
反应条件
in ethanol
1 h; Heating;
参考文献
Harden; Quinn; Scammells
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2892 - 2898
反应条件
triethylamine in ethanol
3 h; Heating / reflux;
参考文献
FUJIFILM Corporation
Patent: EP1975202 A2, 2008 ;
Location in patent: Page/Page column 15; 16 ;
反应条件
diethylamine in ethanol
3 h; Reflux;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; HEISLER, Iring; MÜLLER, Thomas; GOLZ, Stefan; TELSER, Joachim; REHWINKEL, Hartmut; SIEBENEICHER, Holger; BUCHMANN, Bernd; ZORN, Ludwig; EIS, Knut; KOPPITZ, Marcus; LINDNER, Niels; HÉROULT, Mélanie; NEUHAUS, Roland
Patent: WO2013/182612 A1, 2013 ;
Location in patent: Page/Page column 144; 145 ;
反应条件
1: 1.) NaNO2, HCl, 2.) SnCl2, HCl / 1.) H2O, 0 deg C, 2.) H2O, RT, 1 h
2: ethanol / Heating
View Scheme
参考文献
Harden; Quinn; Scammells
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2892 - 2898
参考文献
Harden; Quinn; Scammells
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2892 - 2898
反应条件
1: H2O / 24 h / Heating
2: POCl3; DMF / 4 h / Heating
View Scheme
参考文献
Peat, Andrew J.; Boucheron, Joyce A.; Dickerson, Scott H.; Garrido, Dulce; Mills, Wendy; Peckham, Jennifer; Preugschat, Frank; Smalley, Terrence; Schweiker, Stephanie L.; Wilson, Jayme R.; Wang, Tony Y.; Zhou, Huiqiang Q.; Thomson, Stephen A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2121 - 2125
