6'-溴螺[咪唑烷-5,2'-四氢萘]-2,4-二酮合成路线 （共 9 条）
反应条件
in ethanol; water
T=70°C; Bucherer-Bergs Reaction; 3 h;
参考文献
MERCK and CO., INC.
Patent: WO2006/31676 A2, 2006 ;
Location in patent: Page/Page column 29; 42 ;
WO 2006/031676 A2
反应条件
(NH4)2CO3; water in ethanol
T=70°C; 3 h;
参考文献
MERCK and CO., INC.
Patent: WO2007/16087 A2, 2007 ;
Location in patent: Page/Page column 68-69 ;
WO 2007/016087 A2
反应条件
water in ethanol
T=70°C; 3 h;
参考文献
MERCK and CO., INC.
Patent: WO2007/61676 A2, 2007 ;
Location in patent: Page/Page column 58 ;
WO 2007/061676 A2
反应条件
in ethanol; water
T=70°C; Bucherer-Bergs Reaction; 3 h;
参考文献
MERCK and CO., INC.
Patent: WO2004/87649 A2, 2004 ;
Location in patent: Page 30; 34 ;
WO 2004/087649 A2
反应条件
(NH4)2CO3 in ethanol
1 h; Heating;
参考文献
Oishi, Shinya; Kang, Sang-Uk; Liu, Hongpeng; Zhang, Manchao; Yang, Dajun; Deschamps, Jeffrey R.; Burke Jr., Terrence R.
Tetrahedron, 2004 , vol. 60, # 13 p. 2971 - 2977
反应条件
water in ethanol
T=80°C; Bucherer-Bergs reaction;
参考文献
Cheung, Adrian Wai-Hing; Danho, Waleed; Swistok, Joseph; Qi, Lida; Kurylko, Grazyna; Rowan, Karen; Yeon, Mitch; Franco, Lucia; Chu, Xin-Jie; Chen, Li; Yagaloff, Keith
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 133 - 137
反应条件
1: AlCl3 / 0 °C
2: H2O / ethanol / 80 °C
View Scheme
参考文献
Cheung, Adrian Wai-Hing; Danho, Waleed; Swistok, Joseph; Qi, Lida; Kurylko, Grazyna; Rowan, Karen; Yeon, Mitch; Franco, Lucia; Chu, Xin-Jie; Chen, Li; Yagaloff, Keith
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 133 - 137
反应条件
1: (COCl)2 / dimethylformamide; CH2Cl2 / 0 - 20 °C
2: AlCl3 / 0 °C
3: H2O / ethanol / 80 °C
View Scheme
参考文献
Cheung, Adrian Wai-Hing; Danho, Waleed; Swistok, Joseph; Qi, Lida; Kurylko, Grazyna; Rowan, Karen; Yeon, Mitch; Franco, Lucia; Chu, Xin-Jie; Chen, Li; Yagaloff, Keith
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 133 - 137
反应条件
barium dihydroxide in water
36 h; Heating;
参考文献
Oishi, Shinya; Kang, Sang-Uk; Liu, Hongpeng; Zhang, Manchao; Yang, Dajun; Deschamps, Jeffrey R.; Burke Jr., Terrence R.
Tetrahedron, 2004 , vol. 60, # 13 p. 2971 - 2977
