6-羟基-异吲哚啉-1-酮合成路线 (共 2 条)
反应条件
1: With boron tribromide in dichloromethane T=-78 - 20°C; 18 h; 2: With methanol in dichloromethane T=-78°C; 2 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2004/14856 A1, 2004 ;
Location in patent: Page 10; 23 ;
反应条件
potassium carbonate in acetone
Reflux;
参考文献
Shen, Zhongqi; Siva Ramamoorthy; Hatzenbuhler, Nicole T.; Evrard, Deborah A.; Childers, Wayne; Harrison, Boyd L.; Chlenov, Michael; Hornby, Geoffrey; Smith, Deborah L.; Sullivan, Kelly M.; Schechter, Lee E.; Andree, Terrance H.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 222 - 227