3-(4-溴苯基)-1-丙胺合成路线 （共 11 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
1.5 h; Heating / reflux;
2: With sodium hydroxide in tetrahydrofuran; water
T=20°C;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US2005/137236 A1, 2005 ;
Location in patent: Page/Page column 19 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
5 h;
参考文献
Fujimura, Ken-Ichi; Matsumoto, Junzo; Niwa, Masashi; Kobayashi, Tadayuki; Kawashima, Yoichi; In, Yasuko; Ishida, Toshimasa
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1675 - 1683
反应条件
1: aq. NH3 / diethyl ether / 18.5 h
2: LiAlH4 / tetrahydrofuran / 5 h
View Scheme
参考文献
Fujimura, Ken-Ichi; Matsumoto, Junzo; Niwa, Masashi; Kobayashi, Tadayuki; Kawashima, Yoichi; In, Yasuko; Ishida, Toshimasa
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1675 - 1683
反应条件
1: SOCl2, DMF / CHCl3 / 3.5 h / Heating
2: aq. NH3 / diethyl ether / 18.5 h
3: LiAlH4 / tetrahydrofuran / 5 h
View Scheme
参考文献
Fujimura, Ken-Ichi; Matsumoto, Junzo; Niwa, Masashi; Kobayashi, Tadayuki; Kawashima, Yoichi; In, Yasuko; Ishida, Toshimasa
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1675 - 1683
反应条件
1: NaBH4, aq. NaOH / methanol
2: LiAlH4 / diethyl ether
View Scheme
参考文献
Davies,R.V. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1977 , p. 2357 - 2364
反应条件
lithium aluminium tetrahydride in diethyl ether
Heating;
参考文献
Davies,R.V. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1977 , p. 2357 - 2364
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Davies,R.V. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1977 , p. 2357 - 2364
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Davies,R.V. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1977 , p. 2357 - 2364
反应条件
1: (i) nBuLi, hexane, Et2O, (ii) /BRN= 102378/
3: aq. ethanol
4: LiAlH4 / diethyl ether / Heating
View Scheme
参考文献
Davies,R.V. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1977 , p. 2357 - 2364
反应条件
1: aq. ethanol
2: LiAlH4 / diethyl ether / Heating
View Scheme
参考文献
Davies,R.V. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1977 , p. 2357 - 2364
