1H-吡咯并[3,2-d]嘧啶-2,4(3H,5H)-二酮合成路线 （共 14 条）
反应条件
acetic acid; zinc T=80°C; 2 h;
参考文献
WO2009/62258 A1, ;
Page/Page column 98 ;
WO 2009/062258 A1
反应条件
1: With sodium hydroxide; water 0.5 h; Heating / reflux; 2: With hydrogenchloride in water pH=6;
参考文献
EP1956009 A1, ;
Page/Page column 38 ;
反应条件
1: CH2=CHCH2PPh3(1+)*Br(1-) With lithium hydride in butanone T=20°C; 2: 6-azido-2,4(1H,3H)pyrimidinedione 2 h; Heating;
参考文献
Heteroatom Chemistry, , vol. 13, # 4 p. 357 - 365
反应条件
1: 81.2 percent / dimethylformamide / 0.5 h / 130 - 135 °C 2: 82.46 percent / Zn, acetic acid / 1 h / 70 - 80 °C View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 22, # 2 p. 135 - 141
Khimiko-Farmatsevticheskii Zhurnal, , vol. 22, # 2 p. 185 - 191
反应条件
1: sulfuric acid; nitric acid / 20 °C 2: N,N-dimethyl-formamide / 80 - 140 °C 3: acetic acid; zinc / 80 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 52, p. 205 - 212
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate T=105°C; 6 h; Inert atmosphereReflux; Reagent/catalyst;
参考文献
Zeng, Qi; Huang, Bangzhou; Danielsen, Knut; Shukla, Rajesh; Nagy, Thomas
Organic Process Research and Development, 2004 , vol. 8, # 6 p. 962 - 963
反应条件
dichlorophenyl phosphine oxide; sodium hydroxide T=170 - 180°C; 3 h;
参考文献
Girgis, Nabih S.; Cottam, Howard B.; Larson, Steven B.; Robins, Roland K.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 821 - 827
反应条件
N,N-diethylaniline; trichlorophosphate 48 h; Heating;
参考文献
Modnikova, G. A.; Titkova, R. M.; Glushkov, R. G.; Sokolova, A. S.; Silin, V. A.; Chernov, V. A.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 2 p. 135 - 141
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 2 p. 185 - 191
反应条件
1: 60.6 percent / POCl3 / 6 h / Heating 2: 18 percent / POCl3, diethylaniline / 40 h / Heating 3: 85.2 percent / ethanol / 8.5 h / Heating View Scheme
参考文献
Modnikova, G. A.; Titkova, R. M.; Glushkov, R. G.; Sokolova, A. S.; Silin, V. A.; Chernov, V. A.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 2 p. 135 - 141
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 2 p. 185 - 191
反应条件
1: 60.6 percent / POCl3 / 6 h / Heating 2: 18 percent / POCl3, diethylaniline / 40 h / Heating 3: 80.2 percent / ethanol / 5 h / Heating View Scheme
参考文献
Modnikova, G. A.; Titkova, R. M.; Glushkov, R. G.; Sokolova, A. S.; Silin, V. A.; Chernov, V. A.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 2 p. 135 - 141
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 2 p. 185 - 191
