反应条件
1: 1.) NaH / 1.) ether, 0 deg C, 1 h, 2.) ether, RT, 8 h
2: 98 percent / H2 / 10 percent Pd/C / aq. ethanol / Ambient temperature
3: 100 percent / LiAlH4 / diethyl ether / Ambient temperature
4: Et3N / CH2Cl2 / 2.5 h / 0 - 20 °C
5: NaN3 / dimethylformamide / 3 h / 90 °C
6: 100 percent / LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Furet, Pascal; Gay, Brigitte; Caravatti, Giorgio; Garcia-Echeverria, Carlos; Rahuel, Joseph; Schoepfer, Joseph; Fretz, Heinz
Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3442 - 3449