4,5-二氢-1-[3-(三氟甲基)苯基]-1H-吡唑-3-胺合成路线 (共 7 条)
反应条件
hydrogenchloride; sodium hydroxide in hexane; ethyl acetate
参考文献
Tanabe Seiyaku Co., Ltd.
Patent: US5849732 A1, 1998 ;
反应条件
sodium ethanolate in ethanol
24 h; Heating / reflux;
参考文献
AKZO NOBEL N.V.
Patent: US2007/112034 A1, 2007 ;
Location in patent: Page/Page column 6 ;
反应条件
sodium hydroxide in ethanol
Heating;
参考文献
Frigola; Colombo; Pares; Martinez; Sagarra; Roser
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 4 p. 435 - 445
反应条件
in ethanol; dichloromethane; water
参考文献
American Cyanamid Company
Patent: US4447442 A1, 1984 ;
反应条件
1: 60 percent
2: 76 percent / 1 M sodium hidroxide / ethanol / Heating
View Scheme
参考文献
Frigola; Colombo; Pares; Martinez; Sagarra; Roser
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 4 p. 435 - 445
反应条件
1: 52 percent
2: 60 percent
3: 76 percent / 1 M sodium hidroxide / ethanol / Heating
View Scheme
参考文献
Frigola; Colombo; Pares; Martinez; Sagarra; Roser
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 4 p. 435 - 445
反应条件
N-bromosuccinmide in toluene
1 h; Reflux;
参考文献
GLENMARK PHARMACEUTICALS S.A.; KUMAR, Sukkeerthi; THOMAS, Abraham; WAGHMARE, Nayan, Taterao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil
Patent: WO2011/132017 A1, 2011 ;
Location in patent: Page/Page column 24-25 ;
WO 2011/132017 A1