2-甲基-2-丙基3-(氰基乙酰基)-1-吡咯烷羧酸酯合成路线 （共 2 条）
反应条件
1: acetonitrile With n-butyllithium in tetrahydrofuran
T=-78°C;
2: 1-tert-lt;(butyloxy)carbonylgt;-3-(methoxycarbonyl)-pyrrolidine in tetrahydrofuran
T=-78°C; 10 h;
参考文献
MITSUBISHI PHARMA CORPORATION
Patent: WO2004/14910 A1, 2004 ;
Location in patent: Page 69-70 ;
WO 2004/014910 A1
反应条件
lithium hexamethyldisilazane in tetrahydrofuran
T=-78°C;
参考文献
Dwyer, Michael P.; Paruch, Kamil; Labroli, Marc; Alvarez, Carmen; Keertikar, Kerry M.; Poker, Cory; Rossman, Randall; Fischmann, Thierry O.; Duca, Jose S.; Madison, Vincent; Parry, David; Davis, Nicole; Seghezzi, Wolfgang; Wiswell, Derek; Guzi, Timothy J.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 471 - 474
