2-(3-氯苯基)-琥珀酸合成路线 （共 9 条）
反应条件
hydrogenchloride; water
Reflux;
参考文献
Lv, Wei; Banerjee, Biplab; Molland, Katrina L.; Seleem, Mohamed N.; Ghafoor, Adil; Hamed, Maha I.; Wan, Baojie; Franzblau, Scott G.; Mesecar, Andrew D.; Cushman, Mark
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 406 - 418
反应条件
1: piperidine / toluene / 5 h / |Reflux; |Dean-Stark
2: water; ethanol / 70 °C
3: hydrogenchloride; water / |Reflux
View Scheme
参考文献
Lv, Wei; Banerjee, Biplab; Molland, Katrina L.; Seleem, Mohamed N.; Ghafoor, Adil; Hamed, Maha I.; Wan, Baojie; Franzblau, Scott G.; Mesecar, Andrew D.; Cushman, Mark
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 406 - 418
反应条件
1: water; ethanol / 70 °C
2: hydrogenchloride; water / |Reflux
View Scheme
参考文献
Lv, Wei; Banerjee, Biplab; Molland, Katrina L.; Seleem, Mohamed N.; Ghafoor, Adil; Hamed, Maha I.; Wan, Baojie; Franzblau, Scott G.; Mesecar, Andrew D.; Cushman, Mark
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 406 - 418
反应条件
sodium hydroxide; TiCl3
2.) acetone, 20 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Citterio, Attilio; Cominelli, Alberto; Bonavoglia, Francesco
Synthesis, 1986 , # 4 p. 308 - 309
反应条件
urea in anhydrous xylene
Reflux;
参考文献
Lv, Wei; Banerjee, Biplab; Molland, Katrina L.; Seleem, Mohamed N.; Ghafoor, Adil; Hamed, Maha I.; Wan, Baojie; Franzblau, Scott G.; Mesecar, Andrew D.; Cushman, Mark
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 406 - 418
反应条件
1: thionyl chloride / Reflux
2: AlCl3, aluminium chloride / dichloromethane / 3 h / 20 °C
View Scheme
参考文献
Gan, Zongjie; Zhang, Di; Cao, Zhe; Xu, Yungen
Journal of Chemical Research, 2011 , vol. 35, # 6 p. 317 - 319
反应条件
hydrazine
T=180 - 200°C;
参考文献
Lange; Rump; Borkowska; Kowalczyk; Lapszewicz; Migaj; Walczyna
Pharmazie, 1984 , vol. 39, # 5 p. 318 - 319
反应条件
1: urea / anhydrous xylene / |Reflux
2: borane-THF / tetrahydrofuran / 3.5 h / 0 °C / |Inert atmosphere; |Reflux
View Scheme
参考文献
Lv, Wei; Banerjee, Biplab; Molland, Katrina L.; Seleem, Mohamed N.; Ghafoor, Adil; Hamed, Maha I.; Wan, Baojie; Franzblau, Scott G.; Mesecar, Andrew D.; Cushman, Mark
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 406 - 418
反应条件
1: thionyl chloride / Reflux
2: AlCl3, aluminium chloride / dichloromethane / 3 h / 20 °C
3: triethylsilane; trifluoroacetic acid / 4 h / 40 °C
View Scheme
参考文献
Gan, Zongjie; Zhang, Di; Cao, Zhe; Xu, Yungen
Journal of Chemical Research, 2011 , vol. 35, # 6 p. 317 - 319
