3-氟-5-(甲基羰基)苯甲酸合成路线 (共 2 条)
反应条件
1: With triethylamine; isobutyl chloroformate in dichloromethane T=0 - 20°C; 2 h; 2: With sodium tetrahydroborate in tetrahydrofuran; water 1 h;
参考文献
ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2004/14881 A2, 2004 ;
Location in patent: Page 100-101 ;
WO 2004/014881 A2
反应条件
1: With sodium hydroxide; water in methanol
T=20°C;
2: With hydrogenchloride in water
pH=2;
参考文献
ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2004/14881 A2, 2004 ;
Location in patent: Page 100-101 ;
WO 2004/014881 A2