sodium hydroxide in methanol T=50°C; 1.5 h;

1: 97 percent / hydrogenolyse / 10percent Pd-C / methanol 2: 37 percent / pyridine / diethyl ether / 5.5 h / 2 - 5 °C 3: 18 percent / BF3-etherate / dioxane / 6 h / 51 - 53 °C 4: 50 percent / 4percent aq. NaOH / methanol / 1.5 h / 50 °C View Scheme

1: 79 percent / 1) thallium (III)nitrate trihydrate; 2) 10percent hydrochloric acid; / methanol / 1) 32-35 deg C; 8 h; 2) reflux; 3 h; 2: 97 percent / hydrogenolyse / 10percent Pd-C / methanol 3: 37 percent / pyridine / diethyl ether / 5.5 h / 2 - 5 °C 4: 18 percent / BF3-etherate / dioxane / 6 h / 51 - 53 °C 5: 50 percent / 4percent aq. NaOH / methanol / 1.5 h / 50 °C View Scheme

1: 68 percent / piperidine / ethanol / 6 h / Heating 2: sodium acetate; 3: 79 percent / 1) thallium (III)nitrate trihydrate; 2) 10percent hydrochloric acid; / methanol / 1) 32-35 deg C; 8 h; 2) reflux; 3 h; 4: 97 percent / hydrogenolyse / 10percent Pd-C / methanol 5: 37 percent / pyridine / diethyl ether / 5.5 h / 2 - 5 °C 6: 18 percent / BF3-etherate / dioxane / 6 h / 51 - 53 °C 7: 50 percent / 4percent aq. NaOH / methanol / 1.5 h / 50 °C View Scheme

1: sodium acetate; 2: 79 percent / 1) thallium (III)nitrate trihydrate; 2) 10percent hydrochloric acid; / methanol / 1) 32-35 deg C; 8 h; 2) reflux; 3 h; 3: 97 percent / hydrogenolyse / 10percent Pd-C / methanol 4: 37 percent / pyridine / diethyl ether / 5.5 h / 2 - 5 °C 5: 18 percent / BF3-etherate / dioxane / 6 h / 51 - 53 °C 6: 50 percent / 4percent aq. NaOH / methanol / 1.5 h / 50 °C View Scheme

1: sodium acetate; 2: 79 percent / 1) thallium (III)nitrate trihydrate; 2) 10percent hydrochloric acid; / methanol / 1) 32-35 deg C; 8 h; 2) reflux; 3 h; 3: 97 percent / hydrogenolyse / 10percent Pd-C / methanol 4: 37 percent / pyridine / diethyl ether / 5.5 h / 2 - 5 °C 5: 18 percent / BF3-etherate / dioxane / 6 h / 51 - 53 °C 6: 50 percent / 4percent aq. NaOH / methanol / 1.5 h / 50 °C View Scheme

1: 18 percent / BF3-etherate / dioxane / 6 h / 51 - 53 °C 2: 50 percent / 4percent aq. NaOH / methanol / 1.5 h / 50 °C View Scheme

1: 37 percent / pyridine / diethyl ether / 5.5 h / 2 - 5 °C 2: 18 percent / BF3-etherate / dioxane / 6 h / 51 - 53 °C 3: 50 percent / 4percent aq. NaOH / methanol / 1.5 h / 50 °C View Scheme

1: 18 percent / BF3-etherate / dioxane / 6 h / 51 - 53 °C 2: 50 percent / 4percent aq. NaOH / methanol / 1.5 h / 50 °C View Scheme