1: 4-methyl-n3-(4-pyridin-3-yl-thiazol-2-yl)-benzene-1,3-diamine With trimethylaluminum in hexane; dichloromethane T=5 - 15°C; 2 h; 2: 4-(4-methyl-piperazin-1-methyl)-benzoic acid methyl ester in hexane; dichloromethane T=20°C; 21.1667 h; Heating / reflux; 3: With sodium hydroxide; water in hexane; dichloromethane T=20°C; 3 h; Product distribution / selectivity;

triethylamine in dichloromethane T=0 - 30°C; 10 h; Product distribution / selectivity;

2-chloro-1-methyl-pyridinium iodide in dichloromethane T=20°C; 7 h; Product distribution / selectivity;

hydrogen; nickel in tetrahydrofuran; methanol T=40 - 45°C; P=3677.86 Torr; 2 h;