1-(苄氧基)-2-溴-4-氟苯合成路线 （共 2 条）
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate in DMF (N,N-dimethyl-formamide); aqueous sodium chloride
T=20°C; 1.5 h;
参考文献
TAISHO PHARMACEUTICAL CO., LTD
Patent: EP1528066 A1, 2005 ;
Location in patent: Page/Page column 21 ;
EP 1528066 A1
反应条件
1: boron tribromide / dichloromethane / 2 h / -78 - 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C
View Scheme
参考文献
Mangas-Sanchez, Juan; Busto, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Organic Letters, 2011 , vol. 13, # 20 p. 5711 - 5712
