反应条件
1.1: 79 percent / mCPBA / CH2Cl2 / 18 h
2.1: 90 percent / BF3*Et2O / diethyl ether / 5 h / Heating
3.1: NaHMDS / tetrahydrofuran / 1 h / -78 °C
3.2: 71 percent / tetrahydrofuran / 2 h / -78 °C
4.1: 93.2 percent / aq. HCl / tetrahydrofuran / 20 °C
5.1: 56 percent / NaBH4 / ethanol / 3 h / 0 °C
6.1: aq. NaOH / ethanol / 17 h / Heating
View Scheme
参考文献
Lyles-Eggleston; Altundas; Xia; Sikazwe; Fan; Yang; Li; Zhang; Zhu; Schmidt; Vanase-Frawley; Shrihkande; Villalobos; Borne; Ablordeppey
Journal of Medicinal Chemistry, 2004 , vol. 47, # 3 p. 497 - 508