(R)-2,2-二甲基-恶唑烷-3,4-二甲酸3-叔-丁酯合成路线 （共 4 条）
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine T=20°C; 3 h;
参考文献
Qian, Wenjian; Park, Jung-Eun; Liu, Fa; Lee, Kyung S.; Burke Jr., Terrence R.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 3996 - 4003
反应条件
lithium hydroxide in tetrahydrofuran; water
5.66667 h;
参考文献
Chambers, David J.; Evans, Graham R.; Fairbanks, Antony J.
Tetrahedron Asymmetry, 2005 , vol. 16, # 1 p. 45 - 55
反应条件
1: 4.56 g / BF3*Et2O / acetone / 2 h / 20 °C
2: aq. LiOH / methanol / 6 h / 0 - 20 °C
View Scheme
参考文献
Micale, Nicola; Kozikowski, Alan P.; Ettari, Roberta; Grasso, Silvana; Zappala, Maria; Jeong, Jong-Jin; Kumar, Ajay; Hanspal, Manjit; Chishti, Athar H.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 11 p. 3064 - 3067
反应条件
1: aq. NaHCO3 / tetrahydrofuran / 12 h / 20 °C
2: 4.56 g / BF3*Et2O / acetone / 2 h / 20 °C
3: aq. LiOH / methanol / 6 h / 0 - 20 °C
View Scheme
参考文献
Micale, Nicola; Kozikowski, Alan P.; Ettari, Roberta; Grasso, Silvana; Zappala, Maria; Jeong, Jong-Jin; Kumar, Ajay; Hanspal, Manjit; Chishti, Athar H.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 11 p. 3064 - 3067
