1-甲基-5-硝基-1,3-二氢-2H-苯并咪唑-2-酮合成路线 （共 14 条）
反应条件
phosphorus pentachloride; trichlorophosphate T=190°C;
参考文献
Boehringer Ingelheim Pharma KG
Patent: US6114532 A1, 2000 ;
US 6114532 A
参考文献
van Romburgh; Huyser
Verslag van de Gewone Vergadering van de Afdeling Natuurkunde, Koninklijke Nederlandse Akademie van Wetenschappen, vol. 35, p. 669
Chem. Zentralbl., 1926 , vol. 97, # II p. 2064
反应条件
in N,N-dimethyl-formamide
T=20°C; 2 h;
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara
Patent: WO2012/59932 A1, 2012 ;
Location in patent: Page/Page column 163 ;
WO 2012/059932 A1
反应条件
1,1'-carbonyldiimidazole in tetrahydrofuran; water
参考文献
Boehringer Ingelheim Pharma KG
Patent: US6114532 A1, 2000 ;
US 6114532 A
反应条件
1: triethylamine; formic acid / palladium on activated charcoal / acetonitrile / 4.5 h / -15 - 80 °C
2: N,N-dimethyl-formamide / 2 h / 20 °C
View Scheme
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara
Patent: WO2012/59932 A1, 2012 ;
WO 2012/059932 A1
反应条件
1: ethanol / 15 h / 0 - 20 °C
2: triethylamine; formic acid / palladium on activated charcoal / acetonitrile / 4.5 h / -15 - 80 °C
3: N,N-dimethyl-formamide / 2 h / 20 °C
View Scheme
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara
Patent: WO2012/59932 A1, 2012 ;
WO 2012/059932 A1
反应条件
1: 20 percent / AcOH / ethanol / 15 h / 25 °C
2: 38 percent / AcOH; aq. HCl / 0.25 h / 80 °C
3: 31 percent / methanol / 48 h / 50 °C
4: 51 percent / H2O / methanol / 48 h / 80 °C
View Scheme
参考文献
Kaiya; Fujiwara; Kohda
Chemical Research in Toxicology, 2000 , vol. 13, # 10 p. 993 - 1001
反应条件
1: 31 percent / methanol / 48 h / 50 °C
2: 51 percent / H2O / methanol / 48 h / 80 °C
View Scheme
参考文献
Kaiya; Fujiwara; Kohda
Chemical Research in Toxicology, 2000 , vol. 13, # 10 p. 993 - 1001
反应条件
1: 38 percent / AcOH; aq. HCl / 0.25 h / 80 °C
2: 31 percent / methanol / 48 h / 50 °C
3: 51 percent / H2O / methanol / 48 h / 80 °C
View Scheme
参考文献
Kaiya; Fujiwara; Kohda
Chemical Research in Toxicology, 2000 , vol. 13, # 10 p. 993 - 1001
反应条件
3-chloro-benzenecarboperoxoic acid in chloroform
12 h; Ambient temperature;
参考文献
Kaiya, Toyo; Aoyama, Shinsuke; Kohda, Kohfuku
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 6 p. 625 - 630
