3-O-乙酰基-2-脱氧腺苷酸合成路线 （共 13 条）
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=0°C; 2 h;
参考文献
Wnuk, Stanislaw F.; Yuan, Chong-Sheng; Borchardt, Ronald T.; Balzarini, Jan; De Clercq, Erik; Robins, Morris J.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1608 - 1618
反应条件
PSL in tetrahydrofuran
T=60°C; Acetylation; 48 h;
参考文献
Ciuffreda, Pierangela; Casati, Silvana; Santaniello, Enzo
Tetrahedron, 2000 , vol. 56, # 20 p. 3239 - 3243
反应条件
Pseudomonas Cepacia lipase on ceramic in tetrahydrofuran
T=20°C; Acetylation; 25 h;
参考文献
Nair, Ranjeet V.; Salunkhe, Manikrao M.
Synthetic Communications, 2000 , vol. 30, # 17 p. 3115 - 3120
反应条件
CAL in phosphate buffer; acetone
T=20°C; Deacetylation;
参考文献
Ciuffreda, Pierangela; Casati, Silvana; Santaniello, Enzo
Tetrahedron, 2000 , vol. 56, # 20 p. 3239 - 3243
反应条件
n-butyllithium; 2,2,2-trifluoroethanol in hexane
T=20°C; 3.5 h;
参考文献
Nowak, Ireneusz; Jones, Carl T.; Robins, Morris J.
Journal of Organic Chemistry, 2006 , vol. 71, # 8 p. 3077 - 3081
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran; water
T=20°C; 24 h; Mechanism; regioselective reaction;
参考文献
Babu Kumar, Arun; Manetsch, Roman
European Journal of Organic Chemistry, 2014 , vol. 2014, # 17 p. 3551 - 3555
反应条件
ammonium fluoride in methanol
T=60°C;
参考文献
Zhang, Weijian; Robins, Morris J.
Tetrahedron Letters, 1992 , vol. 33, # 9 p. 1177 - 1180
反应条件
1: 76 percent / pyridine / 7 h / 3 °C
2: 74 percent / TBAF / tetrahydrofuran / 2 h / 0 °C
View Scheme
参考文献
Wnuk, Stanislaw F.; Yuan, Chong-Sheng; Borchardt, Ronald T.; Balzarini, Jan; De Clercq, Erik; Robins, Morris J.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1608 - 1618
反应条件
1: pyridine / 24 h / Ambient temperature
2: 76 percent / pyridine / 7 h / 3 °C
3: 74 percent / TBAF / tetrahydrofuran / 2 h / 0 °C
View Scheme
参考文献
Wnuk, Stanislaw F.; Yuan, Chong-Sheng; Borchardt, Ronald T.; Balzarini, Jan; De Clercq, Erik; Robins, Morris J.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1608 - 1618
反应条件
in 1,4-dioxane
T=60°C; 2 h; Porcine pankreas lipase; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Moris; Gotor
Journal of Organic Chemistry, 1993 , vol. 58, # 3 p. 653 - 660
