1,2-二溴-4-甲基-3-硝基-苯合成路线 （共 5 条）
反应条件
1.1: potassium carbonate / acetonitrile / Reflux 2.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 50 °C 2.2: pH 1 / Reflux View Scheme
参考文献
BAYER SCHERING PHARMA AKTIEGESELLSCHAFT
Patent: US2011/34450 A1, 2011 ;
反应条件
1.1: potassium carbonate / acetonitrile / Reflux
2.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 50 °C
2.2: pH 1 / Reflux
3.1: thionyl chloride / 0.17 h / -10 °C
3.2: 3 h / 20 °C
View Scheme
参考文献
BAYER SCHERING PHARMA AKTIEGESELLSCHAFT
Patent: US2011/34450 A1, 2011 ;
反应条件
1.1: potassium carbonate / acetonitrile / Reflux
2.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 50 °C
2.2: pH 1 / Reflux
3.1: thionyl chloride / 0.17 h / -10 °C
3.2: 3 h / 20 °C
4.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 22 h / 20 °C
View Scheme
参考文献
BAYER SCHERING PHARMA AKTIEGESELLSCHAFT
Patent: US2011/34450 A1, 2011 ;
反应条件
aluminum oxide; water in toluene
T=120°C; 2 h;
参考文献
Favor, David A.; Johnson, Douglas S.; Powers, James J.; Li, Tingsheng; Madabattula, Rambabu
Tetrahedron Letters, 2007 , vol. 48, # 17 p. 3039 - 3041
反应条件
1: 90 percent / alumina; H2O / toluene / 2 h / 120 °C
2: 100 percent / hydrogen / Raney Ni / tetrahydrofuran
View Scheme
参考文献
Favor, David A.; Johnson, Douglas S.; Powers, James J.; Li, Tingsheng; Madabattula, Rambabu
Tetrahedron Letters, 2007 , vol. 48, # 17 p. 3039 - 3041
