1-溴-5-氟-4-甲氧基-2-硝基苯合成路线 （共 3 条）
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide)
T=60°C; 5 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/2047 A2, 2006 ;
Location in patent: Page/Page column 79 ;
反应条件
1: With hydrogen bromide in 1,4-dioxane; water
0.25 h; Heating / reflux;
2: With copper(I) bromide; sodium nitrite in 1,4-dioxane; water
T=0 - 60°C; 1.5 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2005/82879 A1, 2005 ;
Location in patent: Page/Page column 97-98 ;
WO 2005/082879 A1
反应条件
1: With acetic acid; iron in ethanol
T=100°C; 4 h;
2: With potassium carbonate in ethanol
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/2047 A2, 2006 ;
Location in patent: Page/Page column 79-80 ;
