4-(4-氯苯基)-4-羟基-N-甲基-alpha,alpha-二苯基-1-哌啶丁酰胺合成路线 （共 5 条）
反应条件
potassium hydroxide in dimethyl sulfoxide T=80°C; 24 h; Inert atmosphere;
参考文献
Lazarova, Neva; Zoghbi, Sami S.; Hong, Jinsoo; Seneca, Nicholas; Tuan, Ed; Gladding, Robert L.; Liow, Jeih-San; Taku, Andrew; Innis, Robert B.; Pike, Victor W.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 19 p. 6034 - 6043
反应条件
1: thionyl chloride / chloroform / 4 h / |Reflux 2: sodium carbonate / water; toluene / 0 - 20 °C 3: sodium hydroxide / water / pH 12 4: hydrogenchloride / chloroform / 1 h / |Reflux 5: potassium iodide; isobutyl methylketone; sodium carbonate / 80 °C / |Dean-Stark; |Reflux 6: ammonia / water View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 19 p. 5259 - 5263
反应条件
1: sodium carbonate / water; toluene / 0 - 20 °C 2: sodium hydroxide / water / pH 12 3: hydrogenchloride / chloroform / 1 h / |Reflux 4: potassium iodide; isobutyl methylketone; sodium carbonate / 80 °C / |Dean-Stark; |Reflux 5: ammonia / water View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 19 p. 5259 - 5263
反应条件
1: sodium hydroxide / water / pH 12 2: hydrogenchloride / chloroform / 1 h / |Reflux 3: potassium iodide; isobutyl methylketone; sodium carbonate / 80 °C / |Dean-Stark; |Reflux 4: ammonia / water View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 19 p. 5259 - 5263
反应条件
1: hydrogen bromide; acetic acid / 48 h / 20 °C 2: thionyl chloride / chloroform / 4 h / |Reflux 3: sodium carbonate / water; toluene / 0 - 20 °C 4: sodium hydroxide / water / pH 12 5: hydrogenchloride / chloroform / 1 h / |Reflux 6: potassium iodide; isobutyl methylketone; sodium carbonate / 80 °C / |Dean-Stark; |Reflux 7: ammonia / water View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 19 p. 5259 - 5263
