2-(2-溴苄基)丙二酸二乙酯合成路线 （共 22 条）
反应条件
1: 75 percent / aq. KOH / a) reflux, 7 h, b) RT, overnight 2: 81 percent / 5 h / 180 °C 3: 96 percent / borane*THF complex / tetrahydrofuran / 0.5 h / Heating View Scheme
参考文献
Booth; Jenkins; Swain
Journal of the Chemical Society - Series Chemical Communications, 1991 , # 18 p. 1248 - 1249
反应条件
1: 85percent aq. KOH / 2 h / 90 - 100 °C 2: 130 - 195 °C 3: 65 percent / BH3 / tetrahydrofuran / 1 h / 25 °C 4: 66 percent / pyridinium chlorochromate / CH2Cl2 / 3 h / 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 8 p. 1382 - 1396
反应条件
1: NaOH / Heating 2: HCl / Heating 3: 79 percent / H2SO4 / Heating View Scheme
参考文献
Booth; Jenkins; Swain
Journal of the Chemical Society - Series Chemical Communications, 1991 , # 18 p. 1248 - 1249
反应条件
1: 85percent aq. KOH / 2 h / 90 - 100 °C 2: 130 - 195 °C 3: 65 percent / BH3 / tetrahydrofuran / 1 h / 25 °C 4: 66 percent / pyridinium chlorochromate / CH2Cl2 / 3 h / 25 °C 5: 83 percent / diethyl ether / 0 °C 6: 81 percent / pyridinium chlorochromate / CH2Cl2 / 3 h View Scheme
参考文献
Cooke, Manning P.; Widener, Rexford K.
Journal of Organic Chemistry, 1987 , vol. 52, # 8 p. 1382 - 1396
反应条件
1: 89 percent / KOH / acetic acid; H2O; tetrahydrofuran / 12 h / 25 °C 2: 81 percent / 165 °C 3: thionyl chloride / 0.75 h / Heating 4: 93 percent / AlCl3 / CS2 / 3 h / Heating 5: 98 percent / NaBH4 / ethanol / 2 h / 25 °C 6: 92 percent / p-toluenesulfonic acid*H2O / benzene / 1 h / Heating View Scheme
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
反应条件
1: 89 percent / KOH / acetic acid; H2O; tetrahydrofuran / 12 h / 25 °C 2: 81 percent / 165 °C 3: thionyl chloride / 0.75 h / Heating 4: 93 percent / AlCl3 / CS2 / 3 h / Heating 5: 98 percent / NaBH4 / ethanol / 2 h / 25 °C View Scheme
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
反应条件
hydrogenchloride; acetic acid
参考文献
Holliman,F.G. et al.
Journal of the Chemical Society, 1960 , p. 9 - 16
反应条件
1: 89 percent / KOH / acetic acid; H2O; tetrahydrofuran / 12 h / 25 °C 2: 81 percent / 165 °C 3: thionyl chloride / 0.75 h / Heating 4: 93 percent / AlCl3 / CS2 / 3 h / Heating View Scheme
参考文献
Nakazaki,M. et al.
Bulletin of the Chemical Society of Japan, 1961 , vol. 34, p. 1189 - 1194
反应条件
1: 75 percent / aq. KOH / a) reflux, 7 h, b) RT, overnight 2: 81 percent / 5 h / 180 °C 3: 96 percent / borane*THF complex / tetrahydrofuran / 0.5 h / Heating 4: 29 percent / N-iodosuccinimide, Ph3P / CH2Cl2 / Ambient temperature View Scheme
参考文献
Ksander, Gary M.; De Jesus, Reynalda; Yuan, Andrew; Ghai; Trapani; McMartin, Colin; Bohacek, Regine
Journal of Medicinal Chemistry, 1997 , vol. 40, # 4 p. 495 - 505
反应条件
sodium hydride in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=23°C;
参考文献
Negishi, Ei-ichi; Makabe, Hidefumi; Shimoyama, Izumi; Wu, Guangzhong; Zhang, Yantao
Tetrahedron, 1998 , vol. 54, # 7 p. 1095 - 1106
