2-(2-溴苄基)丙二酸二乙酯合成路线 （共 22 条）
反应条件
sodium tetrahydroborate in ethanol
0.5 h;
参考文献
Ksander, Gary M.; De Jesus, Reynalda; Yuan, Andrew; Ghai; Trapani; McMartin, Colin; Bohacek, Regine
Journal of Medicinal Chemistry, 1997 , vol. 40, # 4 p. 495 - 505
反应条件
sodium borohydride in ligroin; ethanol; ethyl acetate; Petroleum ether
参考文献
Jensen, Bo Skaaning; Strobaek, Dorte; Christophersen, Palle; Teuber, Lene; Beyer, Jurgen
Patent: US2002/169203 A1, 2002 ;
反应条件
1: 100 percent / piperidine, benzoic acid / toluene / 3 h / Heating
2: 89 percent / NaBH4 / ethanol / 0.5 h
View Scheme
参考文献
Ksander, Gary M.; De Jesus, Reynalda; Yuan, Andrew; Ghai; Trapani; McMartin, Colin; Bohacek, Regine
Journal of Medicinal Chemistry, 1997 , vol. 40, # 4 p. 495 - 505
反应条件
1: 100 percent / piperidine, benzoic acid / toluene / 3 h / Heating
2: 89 percent / NaBH4 / ethanol / 0.5 h
View Scheme
参考文献
Ksander, Gary M.; De Jesus, Reynalda; Yuan, Andrew; Ghai; Trapani; McMartin, Colin; Bohacek, Regine
Journal of Medicinal Chemistry, 1997 , vol. 40, # 4 p. 495 - 505
反应条件
1: (bromination)
2: (i) NaOEt, (ii) /BRN= 971015/
View Scheme
参考文献
Nakazaki,M. et al.
Bulletin of the Chemical Society of Japan, 1961 , vol. 34, p. 1189 - 1194
反应条件
1: 89 percent / KOH / acetic acid; H2O; tetrahydrofuran / 12 h / 25 °C
2: 81 percent / 165 °C
3: thionyl chloride / 0.75 h / Heating
4: 93 percent / AlCl3 / CS2 / 3 h / Heating
5: 98 percent / NaBH4 / ethanol / 2 h / 25 °C
6: 92 percent / p-toluenesulfonic acid*H2O / benzene / 1 h / Heating
7: 96 percent / NiCl2<dppp>2 / diethyl ether / 22 h / Heating
View Scheme
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
反应条件
1: 89 percent / KOH / acetic acid; H2O; tetrahydrofuran / 12 h / 25 °C
2: 81 percent / 165 °C
3: thionyl chloride / 0.75 h / Heating
4: 93 percent / AlCl3 / CS2 / 3 h / Heating
5: 98 percent / NaBH4 / ethanol / 2 h / 25 °C
6: 92 percent / p-toluenesulfonic acid*H2O / benzene / 1 h / Heating
7: 98 percent / NiCl2<dppp>2 / diethyl ether / Heating
8: 97 percent / H2 / PtO2 / tetrahydrofuran / 1034.3 Torr
View Scheme
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
反应条件
1: 89 percent / KOH / acetic acid; H2O; tetrahydrofuran / 12 h / 25 °C
2: 81 percent / 165 °C
3: thionyl chloride / 0.75 h / Heating
4: 93 percent / AlCl3 / CS2 / 3 h / Heating
5: 98 percent / NaBH4 / ethanol / 2 h / 25 °C
6: 92 percent / p-toluenesulfonic acid*H2O / benzene / 1 h / Heating
7: 96 percent / NiCl2<dppp>2 / diethyl ether / 22 h / Heating
8: 98 percent / H2 / PtO2 / tetrahydrofuran / 1034.3 Torr
View Scheme
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
反应条件
1: 89 percent / KOH / acetic acid; H2O; tetrahydrofuran / 12 h / 25 °C
2: 81 percent / 165 °C
3: thionyl chloride / 0.75 h / Heating
4: 93 percent / AlCl3 / CS2 / 3 h / Heating
5: 98 percent / NaBH4 / ethanol / 2 h / 25 °C
6: 92 percent / p-toluenesulfonic acid*H2O / benzene / 1 h / Heating
7: 99 percent / NiCl2<dppp>2 / diethyl ether / Heating
8: 97 percent / H2 / PtO2 / tetrahydrofuran / 1034.3 Torr
View Scheme
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
反应条件
potassium hydroxide in tetrahydrofuran; water; acetic acid
T=25°C; 12 h;
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
