1-溴-2-溴甲基-4-氯苯合成路线 （共 10 条）
反应条件
N-bromosuccinmide; dibenzoyl peroxide in chloroform T=60°C; 8 h; Inert atmosphere;
参考文献
Hsieh, Jen-Chieh; Cheng, An-Yi; Fu, Jun-Hao; Kang, Ting-Wei
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 31 p. 6404 - 6409
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane T=100°C; 4 h;
参考文献
WO2008/11032 A1, ;
Page/Page column 36-37 ;
反应条件
N-bromosuccinmide; potassium carbonate in N-methyl-acetamide
参考文献
US2003/50320 A1, ;
US 20030050320 A1
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane 48 h; Inert atmosphereReflux;
参考文献
WO2010/122088 A1, ;
Page/Page column 42 ;
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane Reflux;
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 8 p. 2722 - 2730
反应条件
4-methylmorpholine N-oxide in acetonitrile T=0°C; 2 h; Molecular sieve;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA
Patent: WO2006/46030 A2, 2006 ;
Location in patent: Page/Page column 28 ;
反应条件
triethyl phosphite T=115°C; 2 h;
参考文献
WO2008/3460 A1, ;
Page/Page column 17-18 ;
反应条件
1: 1-bromo-2-(bromomethyl)-4-chlorobenzene With triethyl phosphite T=115°C; 2 h; 2: salicylaldehyde With potassium tert-butylate in tetrahydrofuran T=-10°C; Wittig Reaction; 2 h; 3: acetic anhydride in tetrahydrofuran T=-10°C; 0.25 h;
参考文献
N.V. Organon
Patent: US2008/9619 A1, 2008 ;
Location in patent: Page/Page column 8-9 ;
反应条件
1: ethanol / 8 h / Reflux 2: copper(l) iodide; N-acetyl-glycine; potassium iodide; sodium hydroxide / tert-butyl alcohol / 18 h / 100 °C View Scheme
参考文献
Hsieh, Jen-Chieh; Cheng, An-Yi; Fu, Jun-Hao; Kang, Ting-Wei
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 31 p. 6404 - 6409
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 90 °C
1.2: 2 h / 90 °C
2.1: copper(l) iodide; L-proline; potassium carbonate / ethylene glycol / 10 h / 110 °C
View Scheme
参考文献
Zhang, Xinying; Guo, Xiaojie; Fang, Liangliang; Song, Yunping; Fan, Xuesen
European Journal of Organic Chemistry, 2013 , # 36 p. 8087 - 8093
