2,4-二甲基-6-羟基嘧啶合成路线 （共 43 条）
反应条件
1.1: bromine / 1,4-dioxane / 0.75 h / 20 °C
2.1: trichlorophosphate / 3 h / 110 °C
3.1: toluene-4-sulfonic acid hydrazide / chloroform / 16 h / 90 °C
3.2: 1.5 h / 90 °C
View Scheme
参考文献
GLAXOSMITHKLINE LLC; BROWN, Kristin, K.; CHAI, Deping; DODSON, Christopher, S.; DUFFY, Kevin, J.; SHAW, Antony, Nicholas
Patent: WO2013/96151 A1, 2013 ;
反应条件
1: bromine; H2O
2: POCl3
3: methanol; NH3
View Scheme
参考文献
Ochiai; Ito
Yakugaku Zasshi, 1937 , vol. 57, p. 579,581; dtsch. Ref. S. 109, 111
Chem.Abstr., 1937 , p. 6238
反应条件
1: 50 percent / iodine, 1N aq. NaOH / 2 h / Heating
2: 62 percent / POCl3 / toluene / 1 h / Heating
View Scheme
参考文献
Ellingboe, John W.; Collini, Michael D.; Quagliato, Dominick; Chen, James; Antane, Madelene; Schmid, Jean; Hartupee, Dale; White, Valerie; Park, C. Hyung; Tanikella, Tarak; Bagli, Jehan F.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 22 p. 4251 - 4260
