反应条件
1.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C
2.1: tetrahydrofuran; methanol / 20 °C / NaOAc-AcOH buffer
2.2: 2 h / 20 °C
3.1: silver carbonate / N,N-dimethyl-formamide / 100 °C
4.1: bromine / acetic acid / 1 h / 20 °C
4.2: 1 h
5.1: triethylamine / dichloromethane; tetrahydrofuran / 20 °C
5.2: 6 h
View Scheme
参考文献
MYREXIS, INC.; BAJJI, Ashok, C.; TANGALLAPALLY, Rajendra, P.; KIM, In, Chul; KIM, Se, Ho; PARKER, Daniel, P.; TROVATO, Richard; PAPAC, Damon, I.; YAGER, Kraig; BAICHWAL, Vijay, R.
Patent: WO2012/148550 A1, 2012 ;
