2,2,2-三甲基乙酰苯胺合成路线 （共 72 条）
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C 1.2: -78 - 20 °C 1.3: -78 - 20 °C 2.1: hydrogenchloride; water / 1,4-dioxane / 6 h / Reflux 3.1: sodium nitrite / 1,4-dioxane / -5 °C 3.2: -5 - 80 °C View Scheme
参考文献
Cui, Jian-Fang; Huang, Hui; Wong, Henry N. C.
Synlett, 2011 , # 7 p. 1018 - 1022
反应条件
1: sec-BuLi / tetrahydrofuran; hexane / 1.) 0 deg C, 2 h, 2.) 0 deg C, 1 h; r.t., 12 h
2: KHMDS / tetrahydrofuran; hexane; toluene / 2 h / Ambient temperature
View Scheme
参考文献
Ubeda, J. Ignacio; Villacampa, Mercedes; Avendano, Carmen
Synthesis, 1998 , # 8 p. 1176 - 1180
参考文献
Dewar; Scott
Journal of the Chemical Society, 1957 , p. 1445
反应条件
1: sec-BuLi / tetrahydrofuran; hexane / 1.) 0 deg C, 2 h, 2.) 0 deg C, 1 h; r.t., 12 h
2: KHMDS / tetrahydrofuran; hexane; toluene / 2 h / Ambient temperature
View Scheme
参考文献
Ubeda, J. Ignacio; Villacampa, Mercedes; Avendano, Carmen
Synthesis, 1998 , # 8 p. 1176 - 1180
反应条件
sec.-butyllithium; potassium hexamethylsilazane
1.) THF, 0 deg C, 2 h; 2.) THF, 0 deg C, 1 h; 3.) 0 deg C, 10 min; RT, 2h; Yield given. Multistep reaction;
参考文献
Ubeda, J. Ignacio; Villacampa, Mercedes; Avendano, Carmen
Synlett, 1997 , vol. 1997, # 3 p. 285 - 286
反应条件
1.1: trifluoromethanesulfonic anhydride; 2-chloropyridine / CH2Cl2 / -78 - 0 °C
1.2: 83 percent / CH2Cl2; tetrahydrofuran / -78 - 0 °C
2.1: 69 percent / ammonium hexafluorophosphate; 2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl / CpRuCl(PPh3)2 / toluene / 105 °C
View Scheme
参考文献
Movassaghi, Mohammad; Hill, Matthew D.
Journal of the American Chemical Society, 2006 , vol. 128, # 14 p. 4592 - 4593
反应条件
dimethylsulfide borane complex in tetrahydrofuran
T=65°C; 3 h;
参考文献
Krishnamurthy, S.
Tetrahedron Letters, 1982 , vol. 23, # 33 p. 3315 - 3318
反应条件
trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene in chloroform
T=20°C; 0.25 h;
参考文献
Itoh, Naoki; Sakamoto, Takeshi; Miyazawa, Etsuko; Kikugawa, Yasuo
Journal of Organic Chemistry, 2002 , vol. 67, # 21 p. 7424 - 7428
反应条件
N-bromosuccinmide; palladium diacetate; toluene-4-sulfonic acid in toluene
T=20°C; 4 h;
参考文献
Bedford, Robin B.; Haddow, Mairi F.; Mitchell, Charlotte J.; Webster, Ruth L.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 24 p. 5524 - 5527
反应条件
AcOF in dichloromethane; monofluoro-trichloromethane
T=-75°C;
参考文献
Lerman, Ori; Yitzhak, Tor; Hebel, David; Rozen, Shlomo
Journal of Organic Chemistry, 1984 , vol. 49, p. 806 - 813
